Nociceptor sensory neurons protect organisms from danger by eliciting pain and driving
avoidance. Pain also accompanies many types of inflammation and injury. It is increasingly …

The CNS is endowed with an elaborated response repertoire termed'neuroinflammation',
which enables it to cope with pathogens, toxins, traumata and degeneration. On the basis of …

There is burgeoning interest in the interaction between the immune and nervous systems.
Pain is mediated by primary sensory neurons (nociceptors) that can respond to a variety of …

Tumor necrosis factor alpha (TNF-α) was discovered more than a century ago, and its known
roles have extended from within the immune system to include a neuro-inflammatory domain …

Tumor necrosis factor-α (TNFα) is a proinflammatory cytokine involved in the development
and maintenance of inflammatory and neuropathic pain conditions. TNFα can have long …

Tumor necrosis factor-α (TNF) is implicated in the initiation of neuropathic pain. In vitro, TNF
activates p38 mitogen-activated kinase. Accordingly, we investigated whether TNF activates …

Classically, the central nervous system (CNS) and the immune system are thought to
operate independently of each other. This simplistic view has been corrected in recent …

Study Design. Immunohistochemistry for tumor necrosis factor (TNF) and protein gene
product (PGP) 9.5 in vertebral endplates of patients with discogenic low back pain and …

The calcium channel α2δ-1 subunit is a structural subunit important for functional calcium
channel assembly. In vitro studies have shown that this subunit is the binding site for …

Objectives. The purpose of the current study was to evaluate changes in tumor necrosis
factor-α (TNF-α) and TNF-α receptor 1 (p55 receptor) using double fluorescent …