UroPathogenic Escherichia coli (UPEC) Infections: Virulence Factors, Bladder Responses, Antibiotic, and Non-antibiotic Antimicrobial Strategies

ME Terlizzi, G Gribaudo, ME Maffei - Frontiers in microbiology, 2017 - frontiersin.org
Urinary tract infections (UTIs) are one of the most common pathological conditions in both
community and hospital settings. It has been estimated that about 150 million people …

Nonantibiotic prevention and management of recurrent urinary tract infection

N Sihra, A Goodman, R Zakri, A Sahai… - Nature Reviews …, 2018 - nature.com
Urinary tract infections (UTIs) are highly prevalent, lead to considerable patient morbidity,
incur large financial costs to health-care systems and are one of the most common reasons …

Urinary tract infection: Pathogenicity, antibiotic resistance and development of effective vaccines against Uropathogenic Escherichia coli

MRA Karam, M Habibi, S Bouzari - Molecular immunology, 2019 - Elsevier
Urinary tract infections (UTIs) are recognized as one of the most common infectious
diseases in the world that can be divided to different types. Uropathogenic Escherichia coli …

The nature of immune responses to urinary tract infections

SN Abraham, Y Miao - Nature Reviews Immunology, 2015 - nature.com
The urinary tract is constantly exposed to microorganisms that inhabit the gastrointestinal
tract, but generally the urinary tract resists infection by gut microorganisms. This resistance …

Prevention and treatment of uncomplicated lower urinary tract infections in the era of increasing antimicrobial resistance—non-antibiotic approaches: a systemic …

S Wawrysiuk, K Naber, T Rechberger… - Archives of gynecology and …, 2019 - Springer
Abstract Purpose Urinary tract infections (UTIs) are one of the more common infections
encountered in everyday clinical practice. They account for 10–20% of all infections treated …

[HTML][HTML] The impact of biological sex on diseases of the urinary tract

L Deltourbe, LL Mariano, TN Hreha, DA Hunstad… - Mucosal …, 2022 - Elsevier
Biological sex, being female or male, broadly influences diverse immune phenotypes,
including immune responses to diseases at mucosal surfaces. Sex hormones, sex …

[HTML][HTML] Estrogen: the necessary evil for human health, and ways to tame it

S Patel, A Homaei, AB Raju, BR Meher - Biomedicine & Pharmacotherapy, 2018 - Elsevier
Estrogen is a pivotal enzyme for survival and health in both genders, though their quantum,
tropism, tissue-specific distribution, and receptor affinity varies with different phases of life …

Infection in an aging population

KA Kline, DME Bowdish - Current opinion in microbiology, 2016 - Elsevier
Highlights•One third of deaths in adults in the elderly are due to infectious disease.•Changes
in the aging immune response increase the risk of infection in the elderly.•Respiratory …

The immune response to infection in the bladder

L Lacerda Mariano, MA Ingersoll - Nature Reviews Urology, 2020 - nature.com
The bladder is continuously protected by passive defences such as a mucus layer,
antimicrobial peptides and secretory immunoglobulins; however, these defences are …

Diabetes downregulates the antimicrobial peptide psoriasin and increases E. coli burden in the urinary bladder

S Mohanty, W Kamolvit, A Scheffschick… - Nature …, 2022 - nature.com
Diabetes is known to increase susceptibility to infections, partly due to impaired granulocyte
function and changes in the innate immunity. Here, we investigate the effect of diabetes, and …