Mitochondrial DNA damage and reactive oxygen species in neurodegenerative disease
N Nissanka, CT Moraes - FEBS letters, 2018 - Wiley Online Library
Mitochondria are essential organelles within the cell where most ATP is produced through
oxidative phosphorylation (OXPHOS). A subset of the genes needed for this process are …
oxidative phosphorylation (OXPHOS). A subset of the genes needed for this process are …
Mitochondrial dysfunction contributes to neurodegeneration in multiple sclerosis
ME Witte, DJ Mahad, H Lassmann… - Trends in molecular …, 2014 - cell.com
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous
system. Current treatments are very effective in reducing the neuroinflammatory attack, but …
system. Current treatments are very effective in reducing the neuroinflammatory attack, but …
Clinical features of late-onset multiple sclerosis: a systematic review and meta-analysis
A Naseri, E Nasiri, MA Sahraian, S Daneshvar… - Multiple sclerosis and …, 2021 - Elsevier
Background Multiple sclerosis (MS) commonly affects young adults at the ages 20 to 40
years old, but it can onset at each age. Late-onset multiple sclerosis (LOMS) is defined as …
years old, but it can onset at each age. Late-onset multiple sclerosis (LOMS) is defined as …
[HTML][HTML] The potential use of microRNAs as a therapeutic strategy for SARS-CoV-2 infection
J Hu, J Stojanović, S Yasamineh, P Yasamineh… - Archives of …, 2021 - Springer
Abstract Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2). To date, there is no effective therapeutic approach …
syndrome coronavirus 2 (SARS-CoV-2). To date, there is no effective therapeutic approach …
Mitochondria in multiple sclerosis: molecular mechanisms of pathogenesis
Mitochondria, the organelles that function as the powerhouse of the cell, have been
increasingly linked to the pathogenesis of many neurological disorders, including multiple …
increasingly linked to the pathogenesis of many neurological disorders, including multiple …
[HTML][HTML] Mitochondrial genome changes and neurodegenerative diseases
Mitochondria are essential organelles within the cell where most of the energy production
occurs by the oxidative phosphorylation system (OXPHOS). Critical components of the …
occurs by the oxidative phosphorylation system (OXPHOS). Critical components of the …
[HTML][HTML] The dichotomous role of inflammation in the CNS: a mitochondrial point of view
Innate immune response is one of our primary defenses against pathogens infection,
although, if dysregulated, it represents the leading cause of chronic tissue inflammation. This …
although, if dysregulated, it represents the leading cause of chronic tissue inflammation. This …
Mitochondrial DNA sequence variation in multiple sclerosis
GJ Tranah, A Santaniello, SJ Caillier, S D'Alfonso… - Neurology, 2015 - AAN Enterprises
Objective: To assess the influence of common mitochondrial DNA (mtDNA) sequence
variation on multiple sclerosis (MS) risk in cases and controls part of an international …
variation on multiple sclerosis (MS) risk in cases and controls part of an international …
[HTML][HTML] Cell-free mitochondrial DNA in progressive multiple sclerosis
Recent studies have linked cell-free mitochondrial DNA (ccf-mtDNA) to neurodegeneration
in both Alzheimer's and Parkinson's disease, raising the possibility that the same …
in both Alzheimer's and Parkinson's disease, raising the possibility that the same …
[HTML][HTML] In-vitro transcribed mRNA delivery using PLGA/PEI nanoparticles into human monocyte-derived dendritic cells
Z Sharifnia, M Bandehpour… - Iranian Journal of …, 2019 - ncbi.nlm.nih.gov
Induction of protein synthesis by the external delivery of in-vitro transcription-messenger
RNA (IVT-mRNA) has been a useful approach in the realm of cell biology, disease …
RNA (IVT-mRNA) has been a useful approach in the realm of cell biology, disease …