Polymers exhibiting lower critical solution temperatures as a route to thermoreversible gelators for healthcare

MT Cook, P Haddow, SB Kirton… - Advanced Functional …, 2021 - Wiley Online Library
The ability to trigger changes to material properties with external stimuli, so‐called “smart”
behavior, has enabled novel technologies for a wide range of healthcare applications …

Physiological and pharmaceutical considerations for rectal drug formulations

S Hua - Frontiers in pharmacology, 2019 - frontiersin.org
Although the oral route is the most convenient route for drug administration, there are a
number of circumstances where this is not possible from either a clinical or pharmaceutical …

Thermoresponsive gels containing gold nanoparticles as smart antibacterial and wound healing agents

MG Arafa, RF El-Kased, MM Elmazar - Scientific reports, 2018 - nature.com
Thermoresponsive gels containing gold nanoparticles (AuNPs) were prepared using
Pluronic® 127 alone (F1) and with hydroxypropyl methylcellulose (F2) at ratios of 15% w/w …

A review of poloxamer 407 pharmaceutical and pharmacological characteristics

G Dumortier, JL Grossiord, F Agnely… - Pharmaceutical …, 2006 - Springer
Abstract Poloxamer 407 copolymer (ethylene oxide and propylene oxide blocks) shows
thermoreversible properties, which is of the utmost interest in optimising drug formulation …

Demineralized bone matrix carriers and their clinical applications: an overview

H Zhang, L Yang, X Yang, F Wang, J Feng… - Orthopaedic …, 2019 - Wiley Online Library
Reconstruction of massive bone defects is challenging for orthopaedic clinicians, especially
in cases of severe trauma and resection of tumors in various locales. Autologous iliac crest …

Pluronic F-68 and F-127 based nanomedicines for advancing combination cancer therapy

NU Khaliq, J Lee, S Kim, D Sung, H Kim - Pharmaceutics, 2023 - mdpi.com
Pluronics are amphiphilic triblock copolymers composed of two hydrophilic poly (ethylene
oxide)(PEO) chains linked via a central hydrophobic polypropylene oxide (PPO). Owing to …

In situ forming parenteral drug delivery systems: an overview

CB Packhaeuser, J Schnieders, CG Oster… - European Journal of …, 2004 - Elsevier
Biodegradable injectable in situ forming drug delivery systems represent an attractive
alternative to microspheres and implants as parenteral depot systems. Their importance will …

Comparative Study of Heparin-Poloxamer Hydrogel Modified bFGF and aFGF for in Vivo Wound Healing Efficiency

J Wu, J Zhu, C He, Z Xiao, J Ye, Y Li… - … applied materials & …, 2016 - ACS Publications
Wound therapy remains a clinical challenge. Incorporation of growth factors (GFs) into
heparin-functionalized polymer hydrogel is considered as a promising strategy to improve …

Injectable biodegradable temperature-responsive PLGA–PEG–PLGA copolymers: synthesis and effect of copolymer composition on the drug release from the …

M Qiao, D Chen, X Ma, Y Liu - International journal of pharmaceutics, 2005 - Elsevier
Injectable biodegradable temperature-responsive poly (dl-lactide-co-glycolide-b–ethylene
glycol-b-dl-lactide-co-glycolide)(PLGA–PEG–PLGA) triblock copolymers with dl …

In situ mucoadhesive-thermosensitive liposomal gel as a novel vehicle for nasal extended delivery of opiorphin

P Mura, N Mennini, C Nativi, B Richichi - European Journal of …, 2018 - Elsevier
Previous studies proved the effectiveness of an intravenous PEGylated liposomal
formulation of opiorphin (1 mg/mL) in protecting the drug from enzymatic degradation, and …