PrimPol, an archaic primase/polymerase operating in human cells
S García-Gómez, A Reyes, MI Martínez-Jiménez… - Molecular cell, 2013 - cell.com
We describe a second primase in human cells, PrimPol, which has the ability to start DNA
chains with deoxynucleotides unlike regular primases, which use exclusively …
chains with deoxynucleotides unlike regular primases, which use exclusively …
Structure–function studies of DNA polymerase λ
K Bebenek, LC Pedersen, TA Kunkel - Biochemistry, 2014 - ACS Publications
DNA polymerase λ (pol λ) functions in DNA repair with its main roles considered to be filling
short gaps during repair of double-strand breaks by nonhomologous end joining and during …
short gaps during repair of double-strand breaks by nonhomologous end joining and during …
Interactions of Mn complexes with DNA: the relevance of therapeutic applications towards cancer treatment
OM Ganguly, S Moulik - Dalton Transactions, 2023 - pubs.rsc.org
Manganese (Mn) is one of the most significant bio-metals that helps the body to form
connective tissue, bones, blood clotting factors, and sex hormones. It is necessary for fat and …
connective tissue, bones, blood clotting factors, and sex hormones. It is necessary for fat and …
Small molecule interactions with biomacromolecules: DNA binding interactions of a manganese (III) Schiff base complex with potential anticancer activities
A manganese (III) complex,[MnIII (L)(SCN)(enH)](NO3)· H2O (1• H2O)(H2L= 2-((E)-(2-((E)-2-
hydroxy-3-methoxybenzylidene-amino)-ethyl-imino) methyl)-6-methoxyphenol), has been …
hydroxy-3-methoxybenzylidene-amino)-ethyl-imino) methyl)-6-methoxyphenol), has been …
Direct Measurement of the Mn(II) Hydration State in Metal Complexes and Metalloproteins through 17O NMR Line Widths
Here we describe a simple method to estimate the inner-sphere hydration state of the Mn (II)
ion in coordination complexes and metalloproteins. The line width of bulk H217O is …
ion in coordination complexes and metalloproteins. The line width of bulk H217O is …
Increased catalytic activity and altered fidelity of human DNA polymerase ι in the presence of manganese
EG Frank, R Woodgate - Journal of Biological Chemistry, 2007 - ASBMB
All DNA polymerases require a divalent cation for catalytic activity. It is generally assumed
that Mg 2+ is the physiological cofactor for replicative DNA polymerases in vivo. However …
that Mg 2+ is the physiological cofactor for replicative DNA polymerases in vivo. However …
[HTML][HTML] Comparative mechanistic studies of de novo RNA synthesis by flavivirus RNA-dependent RNA polymerases
B Selisko, H Dutartre, JC Guillemot, C Debarnot… - Virology, 2006 - Elsevier
Flavivirus protein NS5 harbors the RNA-dependent RNA polymerase (RdRp) activity. In
contrast to the RdRps of hepaci-and pestiviruses, which belong to the same family of …
contrast to the RdRps of hepaci-and pestiviruses, which belong to the same family of …
Alternative solutions and new scenarios for translesion DNA synthesis by human PrimPol
MI Martínez-Jiménez, S García-Gómez, K Bebenek… - DNA repair, 2015 - Elsevier
PrimPol is a recently described DNA polymerase that has the virtue of initiating DNA
synthesis. In addition of being a sensu stricto DNA primase, PrimPol's polymerase activity …
synthesis. In addition of being a sensu stricto DNA primase, PrimPol's polymerase activity …
Time-lapse crystallography snapshots of a double-strand break repair polymerase in action
JA Jamsen, WA Beard, LC Pedersen, DD Shock… - Nature …, 2017 - nature.com
DNA polymerase (pol) μ is a DNA-dependent polymerase that incorporates nucleotides
during gap-filling synthesis in the non-homologous end-joining pathway of double-strand …
during gap-filling synthesis in the non-homologous end-joining pathway of double-strand …
Plant DNA polymerase λ, a DNA repair enzyme that functions in plant meristematic and meiotic tissues
Y Uchiyama, S Kimura, T Yamamoto… - European Journal of …, 2004 - Wiley Online Library
Little is known about the functions of DNA polymerase λ (Pol λ) recently identified in
mammals. From the genomic sequence information of rice and Arabidopsis, we found that …
mammals. From the genomic sequence information of rice and Arabidopsis, we found that …