4004 ESC Guidelines label use of medication should be limited to situations where it is in
the patient's interest to do so, with regard to the quality, safety, and efficacy of care, and only …

Background: Cardiomyopathies are a heterogeneous group of pathologies characterized by
structural and functional alterations of the heart. Aims: The purpose of this narrative review is …

Dilated cardiomyopathy (DCM) is one of the most common causes of heart failure, and the
underlying mechanism remains largely elusive. Here we investigated whether NLRP3 …

Despite major advancements in cardiovascular medicine, sudden cardiac death (SCD)
continues to be an enormous medical and societal challenge, claiming millions of lives …

Dilated cardiomyopathy (DCM) is characterized by left ventricular dilatation and,
consecutively, contractile dysfunction. The causes of DCM are heterogeneous. DCM often …

Myocarditis can develop into inflammatory cardiomyopathy through chronic stimulation of
myosin heavy chain 6–specific T helper (TH) 1 and TH17 cells. However, mechanisms …

Cardiotoxicity has emerged as a major side effect of doxorubicin (DOX) treatment, affecting
nearly 30% of patients within 5 years after chemotherapy. Heart failure is the first non-cancer …

Inheritable cardiac disorders, which may be associated with cardiomyopathic changes, are
often associated with increased risk of sudden death in the young. Early linkage analysis …

Alcohol has a hormetic physiological behavior that results in either increased or decreased
cardiovascular risk depending on the amount consumed, drinking frequency, pattern of …

Heart disease is the leading cause of death worldwide and imposes a significant burden on
healthcare systems globally. A major hurdle to the development of more effective …