[HTML][HTML] The role of GATA family transcriptional factors in haematological malignancies: A review
GATA transcriptional factors are zinc finger DNA binding proteins that regulate transcription
during development and cell differentiation. The 3 important GATA transcription factors …
during development and cell differentiation. The 3 important GATA transcription factors …
Hematopoietic stem cell factors: their functional role in self-renewal and clinical aspects
Z Mann, M Sengar, YK Verma, R Rajalingam… - Frontiers in Cell and …, 2022 - frontiersin.org
Hematopoietic stem cells (HSCs) possess two important properties such as self-renewal and
differentiation. These properties of HSCs are maintained through hematopoiesis. This …
differentiation. These properties of HSCs are maintained through hematopoiesis. This …
Systematic mapping of functional enhancer–promoter connections with CRISPR interference
Gene expression in mammals is regulated by noncoding elements that can affect physiology
and disease, yet the functions and target genes of most noncoding elements remain …
and disease, yet the functions and target genes of most noncoding elements remain …
PI3k/AKT signaling pathway: Erythropoiesis and beyond
Erythropoiesis is a multi‐step process that involves the differentiation of hematopoietic stem
cells into mature red blood cells (RBCs). This process is regulated by several signaling …
cells into mature red blood cells (RBCs). This process is regulated by several signaling …
Transient activation of c-MYC expression is critical for efficient platelet generation from human induced pluripotent stem cells
N Takayama, S Nishimura, S Nakamura… - Journal of Experimental …, 2010 - rupress.org
Human (h) induced pluripotent stem cells (iPSCs) are a potentially abundant source of blood
cells, but how best to select iPSC clones suitable for this purpose from among the many …
cells, but how best to select iPSC clones suitable for this purpose from among the many …
GATA1 function, a paradigm for transcription factors in hematopoiesis
R Ferreira, K Ohneda, M Yamamoto… - Molecular and cellular …, 2005 - Am Soc Microbiol
The development of mature blood cells of distinct lineages, from the hematopoietic stem
cells (HSCs), involves a progressive restriction of differentiation potential and the …
cells (HSCs), involves a progressive restriction of differentiation potential and the …
GATA transcription factors and cancer
R Zheng, GA Blobel - Genes & cancer, 2010 - journals.sagepub.com
It has been almost a quarter century since it was first appreciated that a class of oncogenes
contained in rapidly transforming avian retroviruses encoded DNA-binding transcription …
contained in rapidly transforming avian retroviruses encoded DNA-binding transcription …
Global regulation of erythroid gene expression by transcription factor GATA-1
JJ Welch, JA Watts, CR Vakoc, Y Yao, H Wang… - Blood, 2004 - ashpublications.org
Transcription factor GATA-1 is required for erythropoiesis, yet its full actions are unknown.
We performed transcriptome analysis of G1E-ER4 cells, a GATA-1–null erythroblast line that …
We performed transcriptome analysis of G1E-ER4 cells, a GATA-1–null erythroblast line that …
Insights into GATA-1-mediated gene activation versus repression via genome-wide chromatin occupancy analysis
The transcription factor GATA-1 is required for terminal erythroid maturation and functions as
an activator or repressor depending on gene context. Yet its in vivo site selectivity and ability …
an activator or repressor depending on gene context. Yet its in vivo site selectivity and ability …
A GATA-1-regulated microRNA locus essential for erythropoiesis
LC Dore, JD Amigo, CO Dos Santos… - Proceedings of the …, 2008 - National Acad Sciences
MicroRNAs (miRNAs) control tissue development, but their mechanism of regulation is not
well understood. We used a gene complementation strategy combined with microarray …
well understood. We used a gene complementation strategy combined with microarray …