Mitochondrial permeability transition (mPT) is a phenomenon that abruptly causes the flux of
low molecular weight solutes (molecular weight up to 1,500) across the generally …

Major progress has been made in defining the basis of the mitochondrial permeability
transition, a Ca2+‐dependent permeability increase of the inner membrane that has puzzled …

Mitochondrial permeability transition pore (mPTP)-dependent cell death is a form of necrotic
cell death that is driven by mitochondrial dysfunction by the opening of the mPTP and is …

In this review, we summarize current knowledge of perhaps one of the most intriguing
phenomena in cell biology: the mitochondrial permeability transition pore (mPTP). This …

The nuclear factor erythroid 2-related factor 2 (Nrf2) is a master regulator of redox balance
and it responds to various cell stresses that oxidative stress is the most well-known one. The …

Endothelial cells (ECs) angiogenesis is the process of sprouting new vessels from the
existing ones, playing critical roles in physiological and pathological processes such as …

Cardiovascular disease is the most common cause of death worldwide and in particular,
ischemic heart disease holds the most considerable position. Even if it has been deeply …

Hepatic ischemia reperfusion injury (HIRI) is a major hurdle in many clinical scenarios,
including liver resection and transplantation. Various studies and countless surgical events …

Ischemia/reperfusion (I/R) injury is characterized by a limited blood supply to organs,
followed by the restoration of blood flow and reoxygenation. In addition to ischemia, blood …

Several drug targets have been amenable to drug discovery pursuit not until the
characterization of the mitochondrial permeability transition pore (MPTP), a pore with an …