Publisher Summary This chapter reviews information on eosinophil structure and function
and provide evidence for the eosinophil as an effector cell for killing helrninths and for …

In mammalian cells, eicosanoid biosynthesis is usually initiated by the activation of
phospholipase A2 and the release of arachidonic acid (AA) from membrane phospholipids …

Eosinophils and T lymphocytes are thought to be involved in allergic airway inflammation.
Both cells express the alpha 4 beta 1-integrin, very late antigen-4 (VLA-4, CD49d/CD29); …

The recent elucidation of chemical structures, metabolism and biological actions of the
leukotriene constituents of slow-reacting substance of anaphylaxis (LTC,, LTD, and LTE,) …

The leukotrienes are a family of biologically active molecules derived from arachidonic acid.
While prostaglandins and thromboxanes are products of the cyclooxygenase pathway of …

Eosinophils, a class of granular leukocytes, are prominent in many inflammatory processes,
particularly in asthma, certain allergic diseases and during infections with helminthic …

Leukotrienes (LT) comprise a group of biologically highly potent lipid mediators synthesized
by 5-lipoxygenase from 20-carbon polyunsaturated fatty acids, predominantly arachidonate …

A simple and improved procedure is described for the isolation of human eosinophils from
normal individuals with about 2% eosinophils in their peripheral blood. This method …

Human platelets dose‐dependently converted exogenous leukotriene A4 to leukotriene C4
and efficiently metabolized this compound to leukotrienes D4 and E4. Neither of these …

1 Neutrophils and eosinophils infiltrate the airways in association with the allergen‐induced
late phase asthmatic reaction. Mobilization of these cells takes place via lipid‐like and …