Cell invasion into the surrounding extracellular matrix or across tissue boundaries and
endothelial barriers occurs in both physiological and pathological scenarios such as …

Simple Summary Matrix stiffness is recognized as a critical factor in cancer progression.
Recent studies have shown that matrix stiffening is caused by the accumulation, contraction …

The cells and tissues of the human body are constantly exposed to exogenous and
endogenous forces that are referred to as biomechanical cues. They guide and impact …

Cell motility is essential for life and development. Unfortunately, cell migration is also linked
to several pathological processes, such as cancer metastasis. Cells' ability to migrate relies …

The tumor extracellular matrix (ECM) plays a vital role in tumor progression and drug
resistance. Previous studies have shown that breast tissue-derived matrices could be an …

The extracellular matrix is a structure composed of many molecules, including fibrillar (types
I, II, III, V, XI, XXIV, XXVII) and non-fibrillar collagens (mainly basement membrane collagens …

Background: Tumorigenesis is attributed to the interactions of cancer cells with the tumor
microenvironment through both biochemical cues and physical stimuli. Increased matrix …

Mechanical cues in the cell microenvironment such as those from extracellular matrix
properties, stretching, compression and shear stress, play a critical role in maintaining …

Background Accumulating studies have shown that tumors are regulated by nerves, and
there is abundant nerve infiltration in the tumor microenvironment. Many solid tumors …

Matrix stiffness is a mechanical characteristic of the extracellular matrix (ECM) that increases
from the tumor core to the tumor periphery in a gradient pattern in a variety of solid tumors …