Many different types of cancer show a high incidence of TP53 mutations, leading to the
expression of mutant p53 proteins. There is growing evidence that these mutant p53s have …

Simple Summary In normal cells, p53 is a protein which regulates the cell cycle progression
to ensure normal cell division, growth, and development. However, in cancer, changes in the …

In humans, the adaptive immune system uses the exchange of information between cells to
detect and eliminate foreign or damaged cells; however, the removal of unwanted cells does …

Chronic hypoxia is associated with a variety of physiological conditions such as rheumatoid
arthritis, ischemia/reperfusion injury, stroke, diabetic vasculopathy, epilepsy and cancer. At …

Abnormal rates of growth together with metastatic potential and lack of susceptibility to
cellular signals leading to apoptosis are widely investigated characteristics of tumors that …

The p53 protein is mutated in about 50% of human cancers. Aside from losing its tumor-
suppressive activities, mutant p53 may acquire pro-oncogenic activity, which is facilitated by …

MicroRNAs are involved in regulating the biology of cancer cells, but their involvement in
chemoresistance is not fully understood. We found that miR-663 was up-regulated in our …

p53 is a tumor suppressor protein that is mutated in more than 50% of cancer cases. When
mutated, it frequently results in p53 oncogenic gain of function (GOF), resulting in a greater …

Pan-cancer studies sketched the genomic landscape of the tumor types spectrum. We
delineated the purity-and ploidy-adjusted allele-specific profiles of 4,950 patients across 27 …

p53 is an important tumor-suppressor protein that is mutated in more than 50% of cancers.
Strategies for restoring normal p53 function are complicated by the oncogenic properties of …