Gastroenteropancreatic (GEP) neuroendocrine neoplasms (NENs) are heterogeneous
regarding site of origin, biological behavior, and malignant potential. There has been a rapid …

Simple Summary Since it was first described over two decades ago, the Alternative
Lengthening of Telomeres (ALT) pathway has been well accepted to hold clinical …

Background and aim The International Cancer of the Pancreas Screening Consortium met in
2018 to update its consensus recommendations for the management of individuals with …

Metastatic and locally-advanced neuroendocrine neoplasms (aNEN) form clinically and
genetically heterogeneous malignancies, characterized by distinct prognoses based upon …

Background & Aims Next-generation sequencing (NGS) of pancreatic cyst fluid is a useful
adjunct in the assessment of patients with pancreatic cyst. However, previous studies have …

Objective Recent studies have found aristaless-related homeobox gene (ARX)/pancreatic
and duodenal homeobox 1 (PDX1), alpha-thalassemia/mental retardation X-linked …

Chromatin accessibility plays an essential role in controlling cellular identity and the
therapeutic response of human cancers. However, the chromatin accessibility landscape …

Recent data suggest that Pancreatic Neuroendocrine Tumours (PanNETs) originate from α-
or β-cells of the islets of Langerhans. The majority of PanNETs are non-functional and do not …

Objective Insulinomas and non-functional pancreatic neuroendocrine tumours (NF-
PanNETs) have distinctive clinical presentations but share similar pathological features …

Abstract Gastroenteropancreatic Neuroendocrine Neoplasms (GEP-NENs) arise throughout
the gut and feature varying biological behaviour and malignant potential. GEP-NENs include …