COVID-19 and the chemical senses: supporting players take center stage
The main neurological manifestation of COVID-19 is loss of smell or taste. The high
incidence of smell loss without significant rhinorrhea or nasal congestion suggests that …
incidence of smell loss without significant rhinorrhea or nasal congestion suggests that …
Progress and renewal in gustation: new insights into taste bud development
LA Barlow - Development, 2015 - journals.biologists.com
The sense of taste, or gustation, is mediated by taste buds, which are housed in specialized
taste papillae found in a stereotyped pattern on the surface of the tongue. Each bud …
taste papillae found in a stereotyped pattern on the surface of the tongue. Each bud …
Possible use of phytochemicals for recovery from COVID-19-induced anosmia and ageusia
The year 2020 became the year of the outbreak of coronavirus, SARS-CoV-2, which
escalated into a worldwide pandemic and continued into 2021. One of the unique symptoms …
escalated into a worldwide pandemic and continued into 2021. One of the unique symptoms …
Inflammation arising from obesity reduces taste bud abundance and inhibits renewal
A Kaufman, E Choo, A Koh, R Dando - PLoS biology, 2018 - journals.plos.org
Despite evidence that the ability to taste is weakened by obesity and can be rescued with
weight loss intervention, few studies have investigated the molecular effects of obesity on …
weight loss intervention, few studies have investigated the molecular effects of obesity on …
WNT10A mutation causes ectodermal dysplasia by impairing progenitor cell proliferation and KLF4-mediated differentiation
M Xu, J Horrell, M Snitow, J Cui, H Gochnauer… - Nature …, 2017 - nature.com
Human WNT10A mutations are associated with developmental tooth abnormalities and
adolescent onset of a broad range of ectodermal defects. Here we show that β-catenin …
adolescent onset of a broad range of ectodermal defects. Here we show that β-catenin …
Taste loss with obesity in mice and men
Background Our sense of taste is critical in defining our food choices and habits. Located
primarily in our tongue, taste buds are small assemblies of constantly renewing sensory …
primarily in our tongue, taste buds are small assemblies of constantly renewing sensory …
Identifying treatments for taste and smell disorders: gaps and opportunities
The chemical senses of taste and smell play a vital role in conveying information about
ourselves and our environment. Tastes and smells can warn against danger and also …
ourselves and our environment. Tastes and smells can warn against danger and also …
Sonic hedgehog from both nerves and epithelium is a key trophic factor for taste bud maintenance
D Castillo-Azofeifa, JT Losacco, E Salcedo… - …, 2017 - journals.biologists.com
The integrity of taste buds is intimately dependent on an intact gustatory innervation, yet the
molecular nature of this dependency is unknown. Here, we show that differentiation of new …
molecular nature of this dependency is unknown. Here, we show that differentiation of new …
The sense of taste: Development, regeneration, and dysfunction
LA Barlow - WIREs mechanisms of disease, 2022 - Wiley Online Library
Gustation or the sense of taste is a primary sense, which functions as a gatekeeper for
substances that enter the body. Animals, including humans, ingest foods that contain …
substances that enter the body. Animals, including humans, ingest foods that contain …
Recovery of taste organs and sensory function after severe loss from Hedgehog/Smoothened inhibition with cancer drug sonidegib
A Kumari, AN Ermilov, M Grachtchouk… - Proceedings of the …, 2017 - National Acad Sciences
Striking taste disturbances are reported in cancer patients treated with Hedgehog (HH)-
pathway inhibitor drugs, including sonidegib (LDE225), which block the HH pathway effector …
pathway inhibitor drugs, including sonidegib (LDE225), which block the HH pathway effector …