COVID-19 and the chemical senses: supporting players take center stage

KW Cooper, DH Brann, MC Farruggia, S Bhutani… - Neuron, 2020 - cell.com
The main neurological manifestation of COVID-19 is loss of smell or taste. The high
incidence of smell loss without significant rhinorrhea or nasal congestion suggests that …

Progress and renewal in gustation: new insights into taste bud development

LA Barlow - Development, 2015 - journals.biologists.com
The sense of taste, or gustation, is mediated by taste buds, which are housed in specialized
taste papillae found in a stereotyped pattern on the surface of the tongue. Each bud …

Possible use of phytochemicals for recovery from COVID-19-induced anosmia and ageusia

S Koyama, K Kondo, R Ueha, H Kashiwadani… - International Journal of …, 2021 - mdpi.com
The year 2020 became the year of the outbreak of coronavirus, SARS-CoV-2, which
escalated into a worldwide pandemic and continued into 2021. One of the unique symptoms …

Inflammation arising from obesity reduces taste bud abundance and inhibits renewal

A Kaufman, E Choo, A Koh, R Dando - PLoS biology, 2018 - journals.plos.org
Despite evidence that the ability to taste is weakened by obesity and can be rescued with
weight loss intervention, few studies have investigated the molecular effects of obesity on …

WNT10A mutation causes ectodermal dysplasia by impairing progenitor cell proliferation and KLF4-mediated differentiation

M Xu, J Horrell, M Snitow, J Cui, H Gochnauer… - Nature …, 2017 - nature.com
Human WNT10A mutations are associated with developmental tooth abnormalities and
adolescent onset of a broad range of ectodermal defects. Here we show that β-catenin …

Taste loss with obesity in mice and men

A Kaufman, J Kim, C Noel, R Dando - International journal of obesity, 2020 - nature.com
Background Our sense of taste is critical in defining our food choices and habits. Located
primarily in our tongue, taste buds are small assemblies of constantly renewing sensory …

Identifying treatments for taste and smell disorders: gaps and opportunities

JD Mainland, LA Barlow, SD Munger, SE Millar… - Chemical …, 2020 - academic.oup.com
The chemical senses of taste and smell play a vital role in conveying information about
ourselves and our environment. Tastes and smells can warn against danger and also …

Sonic hedgehog from both nerves and epithelium is a key trophic factor for taste bud maintenance

D Castillo-Azofeifa, JT Losacco, E Salcedo… - …, 2017 - journals.biologists.com
The integrity of taste buds is intimately dependent on an intact gustatory innervation, yet the
molecular nature of this dependency is unknown. Here, we show that differentiation of new …

The sense of taste: Development, regeneration, and dysfunction

LA Barlow - WIREs mechanisms of disease, 2022 - Wiley Online Library
Gustation or the sense of taste is a primary sense, which functions as a gatekeeper for
substances that enter the body. Animals, including humans, ingest foods that contain …

Recovery of taste organs and sensory function after severe loss from Hedgehog/Smoothened inhibition with cancer drug sonidegib

A Kumari, AN Ermilov, M Grachtchouk… - Proceedings of the …, 2017 - National Acad Sciences
Striking taste disturbances are reported in cancer patients treated with Hedgehog (HH)-
pathway inhibitor drugs, including sonidegib (LDE225), which block the HH pathway effector …