Sepsis affects practically all aspects of endothelial cell (EC) function and is thought to be the
key factor in the progression from sepsis to organ failure. Endothelial functions affected by …

This article presents a personal viewpoint of the shortcoming of conventional hemodynamic
resuscitation procedures in achieving organ perfusion and tissue oxygenation following …

Multiple experimental and human trials have shown that microcirculatory alterations are
frequent in sepsis. In this review, we discuss the various mechanisms that are potentially …

Purpose To discuss the techniques currently available to evaluate the microcirculation in
critically ill patients. In addition, the most clinically relevant microcirculatory alterations will …

Sidestream Dark Field (SDF) imaging, a stroboscopic LED ring-based imaging modality, is
introduced for clinical observation of the microcirculation. SDF imaging is validated by …

Background Experimental and clinical studies have identified a crucial role of
microcirculation impairment in severe infections. We hypothesized that mottling, a sign of …

Introduction Our goal was to assess the effects of titration of a norepinephrine infusion to
increasing levels of mean arterial pressure (MAP) on sublingual microcirculation. Methods …

Purpose To evaluate the effects of fluid administration on microcirculatory alterations in
sepsis. Methods With a Sidestream Dark Field device, we evaluated the effects of fluids on …

Purpose Septic shock has been associated with microvascular alterations and these in turn
with the development of organ dysfunction. Despite advances in video microscopic …

Objective: To determine the relationship between sublingual and intestinal mucosal
microcirculatory perfusion. Design: Observational, experimental study. Setting: University …