Osteoarthritis (OA), characterized by cartilage erosion, synovium inflammation, and
subchondral bone remodeling, is a common joint degenerative disease worldwide. OA …

Bone damage may be triggered by a variety of factors, and the damaged area often requires
a bone graft. Bone tissue engineering can serve as an alternative strategy for repairing large …

Background Wear particles-induced osteolysis is a major long-term complication after total
joint arthroplasty. Up to now, there is no effective treatment for wear particles-induced …

Background Inflammatory osteolysis after total joint replacement (TJR) may cause implant
failure, periprosthetic fractures, and be a severe threat to global public health. Our previous …

Osteoporotic bone defects, a severe complication of osteoporosis, are distinguished by a
delayed bone healing process and poor repair quality. While bone marrow‐derived …

Aseptic loosening (AL), secondary to particle-caused periprosthetic osteolysis, is one of the
main reasons of artificial joint failure. Suppressing the macrophage inflammatory response …

Neurodegenerative disorders affect fifteen percent of the world's population and pose a
significant financial burden to all nations. Cognitive impairment is the seventh leading cause …

Methods and results: Novel work with biological clock genes that oversee circadian rhythm
may meet this critical need by focusing upon the pathways of the mechanistic target of …

Introduction Accelerated imbalance between bone formation and bone resorption is
associated with bone loss in postmenopausal osteoporosis. Studies have shown that this …

Melatonin has not only to be seen as a regulator of circadian clocks. In addition to its
chronobiotic functions, it displays other actions, especially in cell protection. This includes …