Obesity is causally linked with the development of cardiovascular disorders. Accumulating
evidence indicates that cardiovascular disease is the collateral damage of obesity-driven …

Various diseases can cause skeletal muscle atrophy, usually accompanied by inflammation,
mitochondrial dysfunction, apoptosis, decreased protein synthesis, and enhanced …

Impaired insulin-mediated suppression of hepatic glucose production (HGP) plays a major
role in the pathogenesis of type 2 diabetes (T2D), yet the molecular mechanism by which …

Metabolic syndrome (MS) is a collection of cardiometabolic risk factors that includes obesity,
insulin resistance, hypertension, and dyslipidemia. Although there has been significant …

Muscle atrophy is caused by an imbalance in contractile protein synthesis and degradation
which can be triggered by various conditions including Type 2 Diabetes Mellitus (T2DM) …

OBJECTIVE We sought to determine whether exosome-like vesicles (ELVs) released from
adipose tissue play a role in activation of macrophages and subsequent development of …

AMPK (AMP-activated protein kinase) is a key regulator of cellular and whole-body energy
balance. AMPK phosphorylates and regulates many proteins concerned with nutrient …

Aims/hypothesis The role of IL-6 in the development of obesity and hepatic insulin
resistance is unclear and still the subject of controversy. We aimed to determine whether …

The recent major increase in the global incidence of type 2 diabetes suggests that most
cases of this disease are caused by changes in environment and lifestyle. All major risk …

AIMS: The aim of this study was to evaluate the effect of laparoscopic Roux-en-Y gastric
bypass (RYGB) surgery compared with usual care with and without Exenatide therapy in …