Optimization aims to make a system or design as effective or functional as possible.
Mathematical optimization methods are widely used in engineering, economics and science …

The circadian rhythm functions as a master clock that regulates many physiological
processes in humans including sleep, metabolism, hormone secretion, and neurobehavioral …

We describe an innovative experimental and computational approach to control the
expression of a protein in a population of yeast cells. We designed a simple control …

To introduce this special issue on biological switches and clocks, we review the historical
development of mathematical models of bistability and oscillations in chemical reaction …

Circadian entrainment is necessary for rhythmic physiological functions to be appropriately
timed over the 24-hour day. Disruption of circadian rhythms has been associated with sleep …

The widespread adoption of closed-loop control in systems biology has resulted from
improvements in sensors, computing, actuation, and the discovery of alternative sites of …

Systems theoretic tools (ie mathematical modelling, control, and feedback design) advance
the understanding of robust performance in complex biological networks. We highlight …

Light is a strong synchronizer for circadian rhythm—the 24-h biological oscillation in plants,
insects, and mammals. This paper considers the circadian entrainment problem for a …

The field of systems biology studies how the interactions among individual components (eg
genes and proteins) yield interesting and complex behavior. The circadian (daily) …

The paper discusses elementary control strategies to control the phase of an oscillator. Both
feedforward and feedback (P and PI) control laws are designed based on the phase …