CD40 is a cell surface receptor that belongs to the tumor necrosis factor‐R (TNF‐R) family,
and that was first identified and functionally characterized on B lymphocytes. Its critical role …

The development and widespread use of vaccines against infectious agents have been a
great triumph of medical science. One reason for the success of currently available vaccines …

Despite many years of research, human DNA vaccines have yet to fulfill their early promise.
Over the past 15 years, multiple generations of DNA vaccines have been developed and …

Abstract'Naked'nucleic acid vaccines are potentially useful candidates for the treatment of
patients with cancer 1, 2, 3, but their clinical efficacy has yet to be demonstrated. We sought …

Although the field of immunology developed in part from the early vaccine studies of Edward
Jenner, Louis Pasteur and others, vaccine development had largely become the province of …

CD40, a member of the tumor necrosis factor receptor (TNF-R) family, is a surface receptor
best known for its capacity to initiate multifaceted activation signals in normal B cells and …

We studied the role of NK cells in regulating human CD8+ T cell effector function against
mononuclear phagocytes infected with the intracellular pathogen Mycobacterium …

The CD40 receptor is expressed constitutively on B lymphocytes, for which it provides
important signals regulating clonal expansion, antibody production and isotype switching, as …

Abstract The CD40-CD40 ligand (CD40L) interaction is a key event in the initiation of an
adaptive immune response, and as such the therapeutic value of CD40L blockade has been …

Signals generated through CD28–B7 and CD40 ligand (CD40L)–CD40 interactions have
been shown to be crucial for the induction of long-term allograft survivability. We have …