Chemical strategies to engineer hydrogels for cell culture

J Lou, DJ Mooney - Nature Reviews Chemistry, 2022 - nature.com
Two-dimensional and three-dimensional cell culture systems are widely used for biological
studies, and are the basis of the organoid, tissue engineering and organ-on-chip research …

Soft materials by design: unconventional polymer networks give extreme properties

X Zhao, X Chen, H Yuk, S Lin, X Liu… - Chemical Reviews, 2021 - ACS Publications
Hydrogels are polymer networks infiltrated with water. Many biological hydrogels in animal
bodies such as muscles, heart valves, cartilages, and tendons possess extreme mechanical …

Hydrogels and hydrogel-derived materials for energy and water sustainability

Y Guo, J Bae, Z Fang, P Li, F Zhao, G Yu - Chemical reviews, 2020 - ACS Publications
Energy and water are of fundamental importance for our modern society, and advanced
technologies on sustainable energy storage and conversion as well as water resource …

High-strength hydrogels: Fabrication, reinforcement mechanisms, and applications

H Huang, Z Dong, X Ren, B Jia, G Li, S Zhou, X Zhao… - Nano Research, 2023 - Springer
With the continuous appearance and expansion of high-strength hydrogels in emerging
fields such as industry, medicine, and green development, the synthesis and application of …

3D extracellular matrix mimics: fundamental concepts and role of materials chemistry to influence stem cell fate

J Nicolas, S Magli, L Rabbachin, S Sampaolesi… - …, 2020 - ACS Publications
Synthetic 3D extracellular matrices (ECMs) find application in cell studies, regenerative
medicine, and drug discovery. While cells cultured in a monolayer may exhibit unnatural …

Hydrogel scaffolds for tissue engineering: the importance of polymer choice

CD Spicer - Polymer Chemistry, 2020 - pubs.rsc.org
Hydrogel scaffolds that can repair or regrow damaged biological tissue have great potential
for the treatment of injury and disease. These biomaterials are widely used in the tissue …

Advances in crosslinking strategies of biomedical hydrogels

W Hu, Z Wang, Y Xiao, S Zhang, J Wang - Biomaterials science, 2019 - pubs.rsc.org
Biomedical hydrogels as sole repair matrices or combined with pre-seeded cells and
bioactive growth factors are extensively applied in tissue engineering and regenerative …

Click chemistry strategies for the accelerated synthesis of functional macromolecules

Z Geng, JJ Shin, Y Xi, CJ Hawker - Journal of Polymer Science, 2021 - Wiley Online Library
Click chemistry is one of the most powerful strategies for constructing polymeric soft
materials with precise control over architecture and functionality. In this review, we provide a …

Hydrogels based on Schiff base linkages for biomedical applications

J Xu, Y Liu, S Hsu - Molecules, 2019 - mdpi.com
Schiff base, an important family of reaction in click chemistry, has received significant
attention in the formation of self-healing hydrogels in recent years. Schiff base reversibly …

In situ forming injectable hydrogels for drug delivery and wound repair

R Dimatteo, NJ Darling, T Segura - Advanced drug delivery reviews, 2018 - Elsevier
Hydrogels have been utilized in regenerative applications for many decades because of
their biocompatibility and similarity in structure to the native extracellular matrix. Initially …