In the last decades, evidence suggesting the direct or indirect involvement of B cells on
multiple sclerosis (MS) pathogenesis has accumulated. The increased amount of data on …

Multiple sclerosis (MS) is a complex disorder of the central nervous system that appears to
be driven by a shift in immune functioning toward excess inflammation that results in …

Background 'Encephalomyelitis disseminata'(multiple sclerosis) and myalgic
encephalomyelitis/chronic fatigue syndrome (ME/CFS) are both classified as diseases of the …

Rituximab, a chimeric anti-CD20-antibody, attracts increasing attention as a treatment option
for multiple sclerosis (MS). Apart from smaller controlled trials, an increasing number of …

Abstract The World Health Organization classifies myalgic encephalomyelitis/chronic fatigue
syndrome (ME/cfs) as a nervous system disease. Together with other diseases under the …

Chronic obstructive pulmonary disease (COPD) is characterized by a progressive decline in
lung function, caused by exposure to exogenous particles, mainly cigarette smoke (CS) …

Interaction between B and CD4 T cells is crucial for their optimal responses in adaptive
immunity. Immune responses augmented by their partnership promote chronic inflammation …

MicroRNAs (miRNAs) are a recently discovered group of small noncoding RNAs that
regulate gene expression post-transcriptionally. They are highly expressed in cells of the …

The contribution of autoantibody-producing plasma cells in multiple sclerosis (MS) remains
unclear. Anti-CD20 B cell depletion effectively reduces disease activity in MS patients, but it …

Chemobrain is a well-established clinical syndrome that impairs patient's daily function, in
particular attentiveness, coordination and multi-tasking. Thus, it interferes with patient's …