Macrophage-based approaches for cancer immunotherapy
Adoptive cell therapy with genetically modified T cells has generated exciting outcomes in
hematologic malignancies, but its application to solid tumors has proven challenging. This …
hematologic malignancies, but its application to solid tumors has proven challenging. This …
TGFβ control of immune responses in cancer: a holistic immuno-oncology perspective
The immune system responds to cancer in two main ways. First, there are prewired
responses involving myeloid cells, innate lymphocytes and innate-like adaptive lymphocytes …
responses involving myeloid cells, innate lymphocytes and innate-like adaptive lymphocytes …
Combined PD-L1/TGFβ blockade allows expansion and differentiation of stem cell-like CD8 T cells in immune excluded tumors
A Castiglioni, Y Yang, K Williams, A Gogineni… - Nature …, 2023 - nature.com
TGFβ signaling is associated with non-response to immune checkpoint blockade in patients
with advanced cancers, particularly in the immune-excluded phenotype. While previous …
with advanced cancers, particularly in the immune-excluded phenotype. While previous …
Tumor stiffening reversion through collagen crosslinking inhibition improves T cell migration and anti-PD-1 treatment
Only a fraction of cancer patients benefits from immune checkpoint inhibitors. This may be
partly due to the dense extracellular matrix (ECM) that forms a barrier for T cells. Comparing …
partly due to the dense extracellular matrix (ECM) that forms a barrier for T cells. Comparing …
STING suppresses bone cancer pain via immune and neuronal modulation
Patients with advanced stage cancers frequently suffer from severe pain as a result of bone
metastasis and bone destruction, for which there is no efficacious treatment. Here, using …
metastasis and bone destruction, for which there is no efficacious treatment. Here, using …
Preclinical murine tumor models: a structural and functional perspective
The goal of this review is to pinpoint the specific features, including the weaknesses, of
various tumor models, and to discuss the reasons why treatments that are efficient in murine …
various tumor models, and to discuss the reasons why treatments that are efficient in murine …
Transforming growth factor-β: a multifunctional regulator of cancer immunity
VW Xue, JYF Chung, CAG Córdoba, AHK Cheung… - Cancers, 2020 - mdpi.com
Simple Summary Transforming growth factor beta (TGF-β) is a multifunctional cytokine that
can restrict cancer onset but also promote cancer progression at late stages of cancer. The …
can restrict cancer onset but also promote cancer progression at late stages of cancer. The …
Stimulator of IFN genes mediates neuroinflammatory injury by suppressing AMPK signal in experimental subarachnoid hemorrhage
Background Neuroinflammation is closely associated with the poor prognosis in
subarachnoid hemorrhage (SAH) patients. This study was aimed to determine the role of …
subarachnoid hemorrhage (SAH) patients. This study was aimed to determine the role of …
High TGF-β signature predicts immunotherapy resistance in gynecologic cancer patients treated with immune checkpoint inhibition
Y Ni, A Soliman, A Joehlin-Price, PG Rose… - NPJ precision …, 2021 - nature.com
Various immune signatures predictive of resistance to immune checkpoint inhibitors (ICI)
have been described in multiple solid cancers, but still under-investigated in gynecological …
have been described in multiple solid cancers, but still under-investigated in gynecological …
Advances in CAR-T cell genetic engineering strategies to overcome hurdles in solid tumors treatment
AE Andrea, A Chiron, S Mallah, S Bessoles… - Frontiers in …, 2022 - frontiersin.org
During this last decade, adoptive transfer of T lymphocytes genetically modified to express
chimeric antigen receptors (CARs) emerged as a valuable therapeutic strategy in …
chimeric antigen receptors (CARs) emerged as a valuable therapeutic strategy in …