The genetic information of human cells is stored in the context of chromatin, which is
subjected to DNA methylation and various histone modifications. Such a 'language'of …

Mitochondria are not only the main energy supplier but are also the cell metabolic center
regulating multiple key metaborates that play pivotal roles in epigenetics regulation. These …

INTRODUCTION Nucleosomes—the primary, repeating unit of chromatin—package and
protect the genome while also transmitting various regulatory signals through, in part …

Histone modifying enzymes play critical roles in many key cellular processes and are
appealing proteins for targeting by small molecules in disease. However, while the functions …

Simple Summary This review discusses current techniques used to study post-translational
protein modifications (PTMs) and their contribution to blood cancer research. Blood cancer …

Cortical neurogenesis depends on the balance between self‐renewal and differentiation of
apical progenitors (APs). Here, we study the epigenetic control of AP's division mode by …

The glycolytic enzyme, pyruvate kinase Pyk1 maintains telomere heterochromatin by
phosphorylating histone H3T11 (H3pT11), which promotes SIR (silent information regulator) …

Methylation of histone 3 at lysine 79 (H3K79) is one of the principal mechanisms involved in
gene expression. The histone methyltransferase DOT1L, which mono-, di-and trimethylates …

Background Epigenetic regulations play pivotal roles in tumorigenesis and cancer
development. Disruptor of telomeric silencing-1-like (DOT1L), also known as KMT4, is the …

Lung cancer is a lethal malignancy lacking effective therapies. Emerging evidence suggests
that epigenetic enzyme mutations are closely related to the malignant phenotype of lung …