The ligand-stimulated epidermal growth factor receptor (EGFR) has been extensively
studied in the analysis of molecular mechanisms regulating endocytic traffic and the role of …

Focus on the Warburg effect, initially descriptive of increased glycolysis in cancer cells, has
served to illuminate mitochondrial function in many other pathologies. This review explores …

PTP1B, a validated therapeutic target for diabetes and obesity, has a critical positive role in
HER2 signaling in breast tumorigenesis. Efforts to develop therapeutic inhibitors of PTP1B …

The hormonal milieu influences immune tolerance and the immune response against
viruses and cancer, but the direct effect of androgens on cellular immunity remains largely …

Our understanding of the fundamental regulatory roles that tyrosine phosphatases play
within cells has advanced significantly in the last two decades. Out-dated ideas that tyrosine …

Over the past three-decades, Janus kinase (Jak) and signal transducer and activator of
transcription (STAT) signaling has emerged as a paradigm to understand the involvement of …

Since tyrosine phosphorylation is reversible and dynamic in vivo, the phosphorylation state
of proteins is controlled by the opposing roles of protein tyrosine kinases (PTKs) and protein …

By various chromatographic methods, 30 phloroglucinols (1− 30) were isolated from a
methanol extract of Dryopteris crassirhizoma, including two new dimeric phloroglucinols (13 …

This review comprehensively describes the recent advances in the synthesis and
pharmacological evaluation of steroid polyamines squalamine, trodusquemine, ceragenins …

Background Androgen Receptor (AR) is an essential transcription factor for the development
of secondary sex characteristics, spermatogenesis and carcinogenesis. Recently AR has …