DNA-encoded chemical libraries (DELs) represent a versatile and powerful technology
platform for the discovery of small-molecule ligands to protein targets of biological and …

DNA-encoded chemical library technologies are increasingly being adopted in drug
discovery for hit and lead generation. DNA-encoded chemistry enables the exploration of …

The world is totally dependent on medications. As science progresses, new, better, and
cheaper drugs are needed more than ever. The pharmaceutical industry has been …

DNA-encoded synthesis can generate vastly diverse screening libraries of arbitrarily
complex molecules as long as chemical reaction conditions do not compromise DNA's …

Conspectus DNA-encoded chemical libraries (DECLs) represent a promising tool in drug
discovery. DECL technology allows the synthesis and screening of chemical libraries of …

Researchers seeking to improve the efficiency and cost effectiveness of the bioactive small-
molecule discovery process have recently embraced selection-based approaches, which in …

DNA (deoxyribonucleic acid) is the genetic material common to all of Earth's organisms. Our
biological understanding of DNA is extensive and well‐exploited. In recent years, chemists …

The targeted delivery of potent cytotoxic agents has emerged as a promising strategy for the
treatment of cancer and other serious conditions. Traditionally, antibodies against markers of …

DNA-encoded chemical libraries (DECLs) are collections of organic compounds that are
individually linked to different oligonucleotides, serving as amplifiable identification …

Highlights•DNA-encoded chemical libraries: powerful means for hit identification in
pharma.•Link between the chemical building block and an amplifiable genetic …