Autoimmune diseases are a diverse group of conditions characterized by aberrant B cell
and T cell reactivity to normal constituents of the host. These diseases occur widely and …

Genes play a strong role in Alzheimer's disease (AD), with late-onset AD showing heritability
of 58–79% and early-onset AD showing over 90%. Genetic association provides a robust …

The most common cause of acquired thyroid dysfunction is autoimmune thyroid disease,
which is an organ-specific autoimmune disease with two presentation phenotypes …

Genome-wide association studies have identified many variants that each affects multiple
traits, particularly across autoimmune diseases, cancers and neuropsychiatric disorders …

The co-occurrence of diseases can inform the underlying network biology of shared and
multifunctional genes and pathways. In addition, comorbidities help to elucidate the effects …

Clinical and epidemiological data suggest that asthma and allergic diseases are associated
and may share a common genetic etiology. We analyzed genome-wide SNP data for asthma …

Several risk factors for Crohn's disease have been identified in recent genome-wide
association studies. To advance gene discovery further, we combined data from three …

Previous studies have estimated a prevalence of a broad grouping of autoimmune diseases
of 3.2%, based on literature review of studies published between 1965 and 1995, and 5.3 …

Advances in genotyping technology have, over the past decade, enabled the focused
search for common genetic variation associated with human diseases and traits. With the …

Genome-wide association (GWA) studies have identified numerous, replicable, genetic
associations between common single nucleotide polymorphisms (SNPs) and risk of …