The ability to maintain a functional proteome, or proteostasis, declines during the ageing
process. Damaged and misfolded proteins accumulate with age, impairing cell function and …

Members of the highly conserved and ubiquitously expressed pleiotropic CK1 family play
major regulatory roles in many cellular processes including DNA-processing and repair …

Activation of brown adipose tissue-mediated thermogenesis is a strategy for tackling obesity
and promoting metabolic health. BMP8b is secreted by brown/beige adipocytes and …

During viral infection, proper regulation of immune responses is necessary to ensure
successful viral clearance with minimal host tissue damage. Proteasomes play a crucial role …

The life of every organism is dependent on the fine-tuned mechanisms of protein synthesis
and breakdown. The degradation of most intracellular proteins is performed by the ubiquitin …

Model organisms have provided fundamental evidence that aging can be delayed and
longevity extended. These findings gave rise to a new era in aging research aimed at …

In the cell, the proteasome and lysosomes represent the most important proteolytic
machineries, responsible for the protein degradation in the ubiquitin–proteasome system …

Aging is a complex process regulated by multiple cellular pathways, including the
proteostasis network. The proteostasis network consists of molecular chaperones, stress …

Members of the highly conserved pleiotropic CK1 family of serine/threonine-specific kinases
are tightly regulated in the cell and play crucial regulatory roles in multiple cellular …

Humans as diurnal beings are active during the day and rest at night. This daily oscillation of
behavior and physiology is driven by an endogenous circadian clock not environmental …