Bacterial type III secretion systems: specialized nanomachines for protein delivery into target cells

JE Galán, M Lara-Tejero, TC Marlovits… - Annual review of …, 2014 - annualreviews.org
One of the most exciting developments in the field of bacterial pathogenesis in recent years
is the discovery that many pathogens utilize complex nanomachines to deliver bacterially …

Protein export according to schedule: architecture, assembly, and regulation of type III secretion systems from plant-and animal-pathogenic bacteria

D Büttner - Microbiology and Molecular Biology Reviews, 2012 - Am Soc Microbiol
Flagellar and translocation-associated type III secretion (T3S) systems are present in most
Gram-negative plant-and animal-pathogenic bacteria and are often essential for bacterial …

The type III secretion injectisome

GR Cornelis - Nature Reviews Microbiology, 2006 - nature.com
The type III secretion injectisome is a complex nanomachine that allows bacteria to deliver
protein effectors across eukaryotic cellular membranes. In recent years, significant progress …

Protein delivery into eukaryotic cells by type III secretion machines

JE Galán, H Wolf-Watz - Nature, 2006 - nature.com
Bacteria that have sustained long-standing close associations with eukaryotic hosts have
evolved specific adaptations to survive and replicate in this environment. Perhaps one of the …

Type three secretion system in attaching and effacing pathogens

MO Gaytán, VI Martínez-Santos, E Soto… - Frontiers in cellular …, 2016 - frontiersin.org
Enteropathogenic Escherichia coli and enterohemorrhagic E. coli are diarrheagenic
bacterial human pathogens that cause severe gastroenteritis. These enteric pathotypes …

Enteropathogenic and enterohaemorrhagic Escherichia coli: even more subversive elements

ARC Wong, JS Pearson, MD Bright… - Molecular …, 2011 - Wiley Online Library
The human pathogens enteropathogenic and enterohemorrhagic Escherichia coli (EPEC
and EHEC) share a unique mechanism of colonization that results from the concerted action …

Type III protein secretion in plant pathogenic bacteria

D Buttner, SY He - Plant physiology, 2009 - academic.oup.com
Many gram-negative plant and animal pathogenic bacteria employ a type III secretion
system (T3SS) to subvert and colonize their respective host organisms. The T3SS injects …

Enteropathogenic and Enterohemorrhagic Escherichia coli Infections: Translocation, Translocation, Translocation

J Garmendia, G Frankel, VF Crepin - Infection and immunity, 2005 - Am Soc Microbiol
Escherichia coli is the most abundant facultative anaerobic gram-negative bacterium of the
intestinal microffora, naturally colonizing the mucous layer of the colon. A conserved core …

Enteropathogenic Escherichia coli: unravelling pathogenesis

H Deborah Chen, G Frankel - FEMS microbiology reviews, 2005 - academic.oup.com
Enteropathogenic Escherichia coli (EPEC) is a gram-negative bacterial pathogen that
adheres to intestinal epithelial cells, causing diarrhoea. It constitutes a significant risk to …

Process of protein transport by the type III secretion system

P Ghosh - Microbiology and molecular biology reviews, 2004 - Am Soc Microbiol
The type III secretion system (TTSS) of gram-negative bacteria is responsible for delivering
bacterial proteins, termed effectors, from the bacterial cytosol directly into the interior of host …