Glioblastoma (GBM) remains the most lethal and common primary brain tumor, even after
treatment with multiple therapies, such as surgical resection, chemotherapy, and radiation …

Glioblastoma remains the most common and devastating primary brain tumor despite
maximal therapy with surgery, chemotherapy, and radiation. The glioma stem cell (GSC) …

Glial proliferation and activation are associated with disease progression in amyotrophic
lateral sclerosis (ALS) and frontotemporal lobar dementia. In this study, we describe a …

The pathological potential of human astroglia in Alzheimer's disease (AD) was analysed in
vitro using induced pluripotent stem cell (iPSC) technology. Here, we report development of …

A major challenge to our understanding of the molecular mechanisms of Alzheimer's
disease (AD) has been the lack of physiologically relevant in vitro models which capture the …

Non-neuronal cell types such as astrocytes can contribute to Parkinson's disease (PD)
pathology. The G2019S mutation in leucine-rich repeat kinase 2 (LRRK2) is one of the most …

Huntington's disease (HD) causes severe motor dysfunction, behavioral abnormalities,
cognitive impairment and death. Investigations into its molecular pathology have primarily …

Highlights•Higher differentiation efficiency of neurons to astrocytes in RA or GF, or both acts
at the early stage.•bFGF/EGF show superior effects on neuronal differentiation of NSCs over …

Magnetic fields with different frequency and intensity parameters exhibit a wide range of
effects on different biological models. Extremely low frequency magnetic field (ELF MF) …

Background At the earliest stages of brain development, the neuroepithelium works as an
interdependent functional entity together with cerebrospinal fluid, which plays a key …