Over the last several years, the increasing prevalence of obesity has favored an intense
study of adipose tissue biology and the precise mechanisms involved in adipocyte …

Since the discovery nearly 60 years ago, cAMP is envisioned as one of the most universal
and versatile second messengers. The tremendous feature of cAMP to tightly control highly …

Adult stem cells hold great promise as a source of diverse terminally differentiated cell types
for tissue engineering applications. However, due to the complexity of chemical and …

Adipose tissue expansion involves both differentiation of new precursors and size increase
of mature adipocytes. While the two processes are well balanced in healthy tissues, obesity …

In addition to providing skeletal support, the bone is an endocrine organ that produces
osteocalcin, whose uncarboxylated form (GluOC) increases insulin secretion either directly …

Oxylipins are bioactive metabolites derived from the oxygenation of ω3 and ω6
polyunsaturated fatty acids, triggered essentially by cyclooxygenase and lipoxygenase …

The tumor microenvironment (TME) has an impact on breast cancer progression by creating
a pro-inflammatory milieu within the tumor. However, little is known about the roles of …

In vitro adipose tissue models can be used to provide insight into fundamental aspects of
adipose physiology. These systems may serve as replacements for animal models, which …

We investigated the physiological regulation of adiponectin exocytosis in health and
metabolic disease by a combination of membrane capacitance patch-clamp recordings and …

Accumulating evidence indicates that extracellular nucleotides, signaling through purinergic
receptors, play a significant role in bone remodeling. Mesenchymal stem cells (MSCs) …