▪ Abstract With the sequence of the human genome now complete, studies must focus on
how the genome is functionally organized within the confines of the cell nucleus and the …

To elucidate the role of the synaptic protein α-synuclein in neurodegenerative disorders,
transgenic mice expressing wild-type human α-synuclein were generated. Neuronal …

The structural diversity of DNA 3. What forces promote structural isomerizations? 4.
Restrained vs. unrestrained supercoils 5. Supercoiling forces regulate prokaryotic genes 6 …

Steroid receptors bind to site-specific response elements in chromatin and modulate gene
expression in a hormone-dependent fashion. With the use of a tandem array of mouse …

Studies on glucocorticoid receptor (GR) action typically assess gene responses by long-term
stimulation with synthetic hormones. As corticosteroids are released from adrenal glands in …

The generality and spectrum of chromatin-remodeling requirements for nuclear receptor
function are unknown. We have characterized glucocorticoid receptor (GR) binding events …

Exchange of the glucocorticoid receptor (GR) at promoter target sites provides the only
known system in which transcription factor cycling at a promoter is fast, occurring on a time …

Poly (ADP-ribose) polymerase-1 (PARP-1) is an intracellular sensor of DNA strand breaks
and plays a critical role in cellular responses to DNA damage. In normally functioning cells …

Activation of gene transcription involves chromatin remodeling by coactivator proteins that
are recruited by DNA-bound transcription factors. Local modification of chromatin structure at …

Although histone deacetylases (HDACs) are generally viewed as corepressors, we show
that HDAC1 serves as a coactivator for the glucocorticoid receptor (GR). Furthermore, a …