Severe burn injuries are the most traumatic and physically debilitating injuries affecting
nearly every organ system and leading to significant morbidity and mortality. Early burn …

The transient receptor potential vanilloid-1 (TRPV1) is a non-specific cation channel known
for its sensitivity to pungent vanilloid compound (ie capsaicin) and noxious stimuli, including …

Nociception is an important physiological process that detects harmful signals and results in
pain perception. In this review, we discuss important experimental evidence involving some …

Specialized peripheral sensory neurons known as nociceptors alert us to potentially
damaging stimuli at the skin by detecting extremes in temperature and pressure and injury …

Transient receptor potential (TRP) channels are a large family of ion channel proteins,
surpassed in number in mammals only by voltage-gated potassium channels. TRP channels …

Control of chronic pain is frequently inadequate and/or associated with intolerable adverse
effects, prompting a frantic search for new therapeutics and new therapeutic targets. Nearly …

Pain results from the complex processing of neural signals at different levels of the central
nervous system, with each signal potentially offering multiple opportunities for …

Preclinical research has recently uncovered new molecular mechanisms underlying the
generation and transduction of pain, many of which represent opportunities for …

Platinum-based anticancer drugs cause neurotoxicity. In particular, oxaliplatin produces
early-developing, painful, and cold-exacerbated paresthesias. However, the mechanism …

The endocannabinoid system (ECS) is involved in various processes, including brain
plasticity, learning and memory, neuronal development, nociception, inflammation, appetite …