Advanced glycation end-products (AGEs): Formation, chemistry, classification, receptors, and diseases related to AGEs

A Twarda-Clapa, A Olczak, AM Białkowska… - Cells, 2022 - mdpi.com
Advanced glycation end-products (AGEs) constitute a non-homogenous, chemically diverse
group of compounds formed either exogeneously or endogeneously on the course of …

Advanced glycation end products (AGEs) and other adducts in aging-related diseases and alcohol-mediated tissue injury

W Rungratanawanich, Y Qu, X Wang… - … & molecular medicine, 2021 - nature.com
Advanced glycation end products (AGEs) are potentially harmful and heterogeneous
molecules derived from nonenzymatic glycation. The pathological implications of AGEs are …

[HTML][HTML] Protein oxidation-Formation mechanisms, detection and relevance as biomarkers in human diseases

R Kehm, T Baldensperger, J Raupbach, A Höhn - Redox Biology, 2021 - Elsevier
Generation of reactive oxygen species and related oxidants is an inevitable consequence of
life. Proteins are major targets for oxidation reactions, because of their rapid reaction rates …

Neuroprotective natural products for Alzheimer's disease

X Chen, J Drew, W Berney, W Lei - Cells, 2021 - mdpi.com
Alzheimer's disease (AD) is the number one neurovegetative disease, but its treatment
options are relatively few and ineffective. In efforts to discover new strategies for AD therapy …

Neuroprotection against oxidative stress: Phytochemicals targeting TrkB signaling and the Nrf2-ARE antioxidant system

MA Hannan, R Dash, AAM Sohag… - Frontiers in Molecular …, 2020 - frontiersin.org
Oxidative stress (OS) plays a critical role in the pathophysiology of several brain-related
disorders, including neurodegenerative diseases and ischemic stroke, which are the major …

Impairment of insulin signaling pathway PI3K/Akt/mTOR and insulin resistance induced AGEs on diabetes mellitus and neurodegenerative diseases: a perspective …

K Ramasubbu, V Devi Rajeswari - Molecular and Cellular Biochemistry, 2023 - Springer
Insulin resistance is common in type 2 diabetes mellitus (T2DM), neurodegenerative
diseases, cardiovascular diseases, kidney diseases, and polycystic ovary syndrome …

A role for advanced glycation end products in molecular ageing

K Zgutka, M Tkacz, P Tomasiak… - International journal of …, 2023 - mdpi.com
Ageing is a composite process that involves numerous changes at the cellular, tissue, organ
and whole-body levels. These changes result in decreased functioning of the organism and …

Protein carbonylation in food and nutrition: a concise update

M Estévez, S Díaz-Velasco, R Martínez - Amino Acids, 2022 - Springer
Protein oxidation is a topic of indisputable scientific interest given the impact of oxidized
proteins on food quality and safety. Carbonylation is regarded as one of the most notable …

The link between oxidative stress, mitochondrial dysfunction and neuroinflammation in the pathophysiology of Alzheimer's disease: therapeutic implications and future …

MC Jurcău, FL Andronie-Cioara, A Jurcău, F Marcu… - Antioxidants, 2022 - mdpi.com
Alzheimer's disease (AD), the most common form of dementia, has increasing incidence,
increasing mortality rates, and poses a huge burden on healthcare. None of the currently …

The effects of dietary advanced glycation end-products on neurocognitive and mental disorders

NM D'cunha, D Sergi, MM Lane, N Naumovski… - Nutrients, 2022 - mdpi.com
Advanced glycation end products (AGEs) are glycated proteins or lipids formed
endogenously in the human body or consumed through diet. Ultra-processed foods and …