Proteinopathy and neuroinflammation are two main hallmarks of neurodegenerative
diseases. They also represent rare common events in an exceptionally broad landscape of …

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are fatal
neurodegenerative disorders on a disease spectrum that are characterized by the …

We have recently identified the aberrant nuclear accumulation of the ESCRT-III protein
CHMP7 as an initiating event that leads to a significant injury to the nuclear pore complex …

Background Cytoplasmic mislocalization and aggregation of TAR DNA-binding protein-43
(TDP-43) is a hallmark of the amyotrophic lateral sclerosis and frontotemporal dementia …

The G4C2 repeat expansion in the C9orf72 gene is the most common genetic cause of
Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Many studies suggest that …

Nuclear pore complexes (NPCs) play a critical role in maintaining the equilibrium between
the nucleus and cytoplasm, enabling bidirectional transport across the nuclear envelope …

GEMIN5 is essential for core assembly of small nuclear Ribonucleoproteins (snRNPs), the
building blocks of spliceosome formation. Loss-of-function mutations in GEMIN5 lead to a …

Biomolecular condensates are important contributors to the internal organization of the cell
material. While initially described as liquid-like droplets, the term biomolecular condensates …

Nucleoporins (Nups) assemble nuclear pores that form the permeability barrier between
nucleoplasm and cytoplasm. Nucleoporins also localize in cytoplasmic foci proposed to …

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are two adult-onset
neurodegenerative diseases that are part of a common disease spectrum due to clinical …