Human topoisomerases comprise a family of six enzymes: two type IB (TOP1 and
mitochondrial TOP1 (TOP1MT), two type IIA (TOP2A and TOP2B) and two type IA (TOP3A …

Hydroxyurea (HU) is mostly referred to as an inhibitor of ribonucleotide reductase (RNR)
and as the agent that is commonly used to arrest cells in the S-phase of the cycle by …

RPA has been shown to protect single-stranded DNA (ssDNA) intermediates from instability
and breakage. RPA binds ssDNA with sub-nanomolar affinity, yet dynamic turnover is …

DNA damage repair response is an important biological process involved in maintaining the
fidelity of the genome in eukaryotes and prokaryotes. Several proteins that play a key role in …

SUMOylation regulates numerous cellular processes, but what represents the essential
functions of this protein modification remains unclear. To address this, we performed …

Bloom's syndrome (BLM) protein is a known nuclear helicase that is able to unwind DNA
secondary structures such as G-quadruplexes (G4s). However, its role in the regulation of …

Transcriptionally active loci are particularly prone to breakage and mounting evidence
suggests that DNA Double-Strand Breaks arising in active genes are handled by a …

The Bloom syndrome helicase BLM interacts with topoisomerase IIIα (TOP3A), RMI1, and
RMI2 to form the BTR complex, which dissolves double Holliday junctions and DNA …

Autosomal hereditary recessive diseases characterized by genetic instability are often
associated with cancer predisposition. Bloom syndrome (BS), a rare genetic disorder, with< …

Co-transcriptional R loops arise from stalling of RNA polymerase, leading to the formation of
stable DNA: RNA hybrids. Unresolved R loops promote genome instability but are …