[HTML][HTML] Autophagy orchestrates resistance in hepatocellular carcinoma cells

H Seydi, K Nouri, N Rezaei, A Tamimi… - Biomedicine & …, 2023 - Elsevier
Abstract Treatment resistance is one of the major barriers for therapeutic strategies in
hepatocellular carcinoma (HCC). Many studies have indicated that chemotherapy and …

Molecular hallmarks of long non-coding RNAs in aging and its significant effect on aging-associated diseases

SAM Sherazi, A Abbasi, A Jamil, M Uzair… - Neural Regeneration …, 2023 - journals.lww.com
Aging is linked to the deterioration of many physical and cognitive abilities and is the leading
risk factor for Alzheimer's disease. The growing aging population is a significant healthcare …

The lncRNA Malat1 is trafficked to the cytoplasm as a localized mRNA encoding a small peptide in neurons

W Xiao, R Halabi, CH Lin, M Nazim… - Genes & …, 2024 - genesdev.cshlp.org
Synaptic function in neurons is modulated by local translation of mRNAs that are transported
to distal portions of axons and dendrites. The metastasis‐associated lung adenocarcinoma …

Structural basis of MALAT1 RNA maturation and mascRNA biogenesis

I Skeparnias, C Bou-Nader, DG Anastasakis… - Nature Structural & …, 2024 - nature.com
The metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) long noncoding
RNA (lncRNA) has key roles in regulating transcription, splicing, tumorigenesis, etc. Its …

Phytic Acid Maintains the Integrity of the Blood–Milk Barrier by Regulating Inflammatory Response and Intestinal Flora Structure

X Ran, J Liu, S Fu, F He, K Li, G Hu… - Journal of Agricultural …, 2021 - ACS Publications
The destruction of the blood–milk barrier (BMB) caused by the mammary inflammatory
response (MIR) is one of the main reasons that hinders breastfeeding. To relieve the …

LINC00478-derived novel cytoplasmic lncRNA LacRNA stabilizes PHB2 and suppresses breast cancer metastasis via repressing MYC targets

R Guo, Y Su, Q Zhang, B Xiu, S Huang, W Chi… - Journal of Translational …, 2023 - Springer
Background Metastasis is the predominant cause of mortality in patients with breast cancer.
Long noncoding RNAs (lncRNAs) have been shown to drive important phenotypes in …

Cellular and molecular activities of IP6 in disease prevention and therapy

L Dilworth, D Stennett, F Omoruyi - Biomolecules, 2023 - mdpi.com
IP6 (phytic acid) is a naturally occurring compound in plant seeds and grains. It is a poly-
phosphorylated inositol derivative that has been shown to exhibit many biological activities …

Non-coding RNA related to MAPK signaling pathway in liver cancer

Q Wang, J Feng, L Tang - International journal of molecular sciences, 2022 - mdpi.com
The advancement in high-throughput sequencing analysis and the evaluation of chromatin
state maps have revealed that eukaryotic cells produce many non-coding transcripts/RNAs …

Exploring the role of mitochondria transfer/transplant and their long-non-coding RNAs in regenerative therapies for skin aging

S Peñaherrera, C Ruiz, V Castañeda, K Livingston… - Mitochondrion, 2023 - Elsevier
Advancing age and environmental stressors lead to mitochondrial dysfunction in the skin,
inducing premature aging, impaired regeneration, and greater risk of cancer. Cells rely on …

[HTML][HTML] Deconstructing the role of MALAT1 in MAPK-signaling in melanoma: insights from antisense oligonucleotide treatment

V Feichtenschlager, YJ Zheng, W Ho, L Chen… - Oncotarget, 2023 - ncbi.nlm.nih.gov
The long non-coding RNA (lncRNA) MALAT1 is a regulator of oncogenesis and cancer
progression. MAPK-pathway upregulation is the main event in the development and …