Advances of medical nanorobots for future cancer treatments

X Kong, P Gao, J Wang, Y Fang, KC Hwang - Journal of Hematology & …, 2023 - Springer
Early detection and diagnosis of many cancers is very challenging. Late stage detection of a
cancer always leads to high mortality rates. It is imperative to develop novel and more …

Understanding ultrasound induced sonoporation: definitions and underlying mechanisms

I Lentacker, I De Cock, R Deckers, SC De Smedt… - Advanced drug delivery …, 2014 - Elsevier
In the past two decades, research has underlined the potential of ultrasound and
microbubbles to enhance drug delivery. However, there is less consensus on the …

Microbubbles in ultrasound-triggered drug and gene delivery

S Hernot, AL Klibanov - Advanced drug delivery reviews, 2008 - Elsevier
Ultrasound contrast agents, in the form of gas-filled microbubbles, are becoming popular in
perfusion monitoring; they are employed as molecular imaging agents. Microbubbles are …

Micro/nanorobot: A promising targeted drug delivery system

M Hu, X Ge, X Chen, W Mao, X Qian, WE Yuan - Pharmaceutics, 2020 - mdpi.com
Micro/nanorobot, as a research field, has attracted interest in recent years. It has great
potential in medical treatment, as it can be applied in targeted drug delivery, surgical …

[HTML][HTML] Mechanisms underlying sonoporation: Interaction between microbubbles and cells

Y Yang, Q Li, X Guo, J Tu, D Zhang - Ultrasonics Sonochemistry, 2020 - Elsevier
The past several decades have witnessed great progress in “smart drug delivery”, an
advance technology that can deliver genes or drugs into specific locations of patients' body …

[HTML][HTML] Combining microbubbles and ultrasound for drug delivery to brain tumors: current progress and overview

HL Liu, CH Fan, CY Ting, CK Yeh - Theranostics, 2014 - ncbi.nlm.nih.gov
Malignant glioma is one of the most challenging central nervous system (CNS) diseases,
which is typically associated with high rates of recurrence and mortality. Current surgical …

Vibrating microbubbles poking individual cells: drug transfer into cells via sonoporation

A Van Wamel, K Kooiman, M Harteveld… - Journal of controlled …, 2006 - Elsevier
Ultrasound contrast microbubbles have the ability to enhance endothelial cell permeability
and thus may be used as a new way to deliver drugs. It facilitates the transfer of extracellular …

[HTML][HTML] Ultrasound-mediated drug delivery: sonoporation mechanisms, biophysics, and critical factors

CH YuAlfred - BME frontiers, 2022 - spj.science.org
Sonoporation, or the use of ultrasound in the presence of cavitation nuclei to induce plasma
membrane perforation, is well considered as an emerging physical approach to facilitate the …

Mechanistic understanding the bioeffects of ultrasound-driven microbubbles to enhance macromolecule delivery

P Qin, T Han, CH Alfred, L Xu - Journal of controlled release, 2018 - Elsevier
Ultrasound-driven microbubbles can trigger reversible membrane perforation
(sonoporation), open interendothelial junctions and stimulate endocytosis, thereby providing …

Microbubbles and ultrasound: from diagnosis to therapy

PA Dijkmans, LJM Juffermans… - European Journal of …, 2004 - academic.oup.com
The development of ultrasound contrast agents, containing encapsulated microbubbles, has
increased the possibilities for diagnostic imaging. Ultrasound contrast agents are currently …