Microfluidics, a toolbox comprising methods for precise manipulation of fluids at small length
scales (micrometers to millimeters), has become useful for manipulating cells. Its uses range …

Single-cell analysis (SCA) has been increasingly recognized as the key technology for the
elucidation of cellular functions, which are not accessible from bulk measurements on the …

Microfluidic devices have been widely applied to trapping and isolation of cells and clusters
for controllable intercellular environments and high-throughput analysis, triggering …

Single cell investigations have enabled unexpected discoveries, such as the existence of
biological noise and phenotypic switching in infection, metabolism and treatment. Herein …

Manipulation of microorganisms with intrinsic motility is a challenging yet important task for
many biological and biomedical applications. Currently, such a task has only been …

In this paper, for the first time, an on-chip optofluidic imaging system is innovated to measure
the biophysical signatures of single waterborne bacteria, including both their refractive …

Various single-cell retention structures (SCRSs) were reported for analysis of single cells
within microfluidic devices. Undesirable flow behaviors within micro-environments not only …

We present a novel centrifugal microfluidic platform for the highly efficient manipulation and
analysis of particles for applications in bead-based assays. The platform uses an array of …

Cellular metabolic heat (ΔP M) is produced from intracellular reactions, carrying information
about particular processes thus indicating the status of organisms. ΔP M originating from a …

There is an urgent need to develop novel methods for assessing the response of bacteria to
antibiotics in a timely manner. Antibiotics are traditionally assessed via their effect on …