Osteoarthritis (OA) is a widespread clinical disease characterized by cartilage degeneration
in middle-aged and elderly people. Currently, there is no effective treatment for OA apart …

Articular cartilage injury is a frequent worldwide disease, while effective treatment is urgently
needed. Due to lack of blood vessels and nerves, the ability of cartilage to self-repair is …

summary Great progress continues to be made in our understanding of the multiple facets of
osteoarthritis (OA) biology. Here, we review the major advances in this field and progress …

Aberrant subchondral bone architecture is a crucial driver of the pathological progression of
osteoarthritis, coupled with increased sensory innervation. The sensory PGE2/EP4 pathway …

Nowadays, small-molecule drugs have become an indispensable part of tumor
immunotherapy. Accumulating evidence has indicated that specifically blocking PGE2/EP4 …

Osteoarthritis (OA) is a complex disease characterized by cartilage degeneration and
persistent pain. Prostaglandin E2 (PGE2) plays a significant role in OA inflammation and …

The interoception maintains proper physiological conditions and metabolic homeostasis by
releasing regulatory signals after perceving changes in the internal state of the organism …

Abstract Objective Nanoparticles (NPs) hold a great promise in combating rheumatoid
arthritis, but are often compromised by their toxicities because the currently used NPs are …

China's aging demographic poses a challenge for treating prevalent bone diseases
impacting life quality. As bone regeneration capacity diminishes with age due to cellular …

Accumulating evidence indicates that interoception maintains proper physiological status
and orchestrates metabolic homeostasis by regulating feeding behaviors, glucose balance …