Cytokine dysregulation is believed to play a key role in the remodeling of the immune
system at older age, with evidence pointing to an inability to fine-control systemic …

Abstract In 2011, the National Institute on Aging and Alzheimer's Association created
separate diagnostic recommendations for the preclinical, mild cognitive impairment, and …

Genomic instability, telomere attrition, epigenetic alterations, mitochondrial dysfunction, loss
of proteostasis, deregulated nutrient-sensing, cellular senescence, stem cell exhaustion …

Aging is a dynamic, time-dependent process that is characterized by a gradual accumulation
of cell damage. Continual functional decline in the intrinsic ability of living organisms to …

Cellular senescence is a stress response mechanism ensuring homeostasis. Its temporal
activation during embryonic development or normal adult life is linked with beneficial …

During leaf senescence, the final stage of leaf development, nutrients are recycled from
leaves to other organs, and therefore proper control of senescence is thus critical for plant …

In response to persistent DNA damage, induction into cell senescence promotes an
immunogenic program which facilitates immune clearance of these damaged cells. Under …

Cellular senescence is now considered as a major mechanism in the development and
progression of various diseases and this may include metabolic diseases such as obesity …

Senescence is a state of cell cycle arrest that plays an important role in embryogenesis,
wound healing and protection against cancer. Senescent cells also accumulate during …

Aging is emerging as a druggable target with growing interest from academia, industry and
investors. New technologies such as artificial intelligence and advanced screening …