Clinical and experimental insight into pathophysiology, comorbidity and therapy of absence seizures
Absence seizures in children and teenagers are generally considered relatively benign
because of their non-convulsive nature and the large incidence of remittance in early …
because of their non-convulsive nature and the large incidence of remittance in early …
Therapeutic approaches to genetic ion channelopathies and perspectives in drug discovery
P Imbrici, A Liantonio, GM Camerino… - Frontiers in …, 2016 - frontiersin.org
In the human genome more than 400 genes encode ion channels, which are
transmembrane proteins mediating ion fluxes across membranes. Being expressed in all …
transmembrane proteins mediating ion fluxes across membranes. Being expressed in all …
Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals
Here we conducted a large-scale genetic association analysis of educational attainment in a
sample of approximately 1.1 million individuals and identify 1,271 independent genome …
sample of approximately 1.1 million individuals and identify 1,271 independent genome …
A genetically encoded fluorescent acetylcholine indicator for in vitro and in vivo studies
The neurotransmitter acetylcholine (ACh) regulates a diverse array of physiological
processes throughout the body. Despite its importance, cholinergic transmission in the …
processes throughout the body. Despite its importance, cholinergic transmission in the …
[HTML][HTML] Gene discovery and polygenic prediction from a 1.1-million-person GWAS of educational attainment
We conduct a large-scale genetic association analysis of educational attainment in a sample
of~ 1.1 million individuals and identify 1,271 independent genome-wide-significant SNPs …
of~ 1.1 million individuals and identify 1,271 independent genome-wide-significant SNPs …
Ras and Rap signal bidirectional synaptic plasticity via distinct subcellular microdomains
How signaling molecules achieve signal diversity and specificity is a long-standing cell
biology question. Here we report the development of a targeted delivery method that permits …
biology question. Here we report the development of a targeted delivery method that permits …
Cav3. 1-driven bursting firing in ventromedial hypothalamic neurons exerts dual control of anxiety-like behavior and energy expenditure
J Shao, DS Gao, YH Liu, SP Chen, N Liu, L Zhang… - Molecular …, 2022 - nature.com
The central nervous system has evolved to coordinate the regulation of both the behavior
response to the external environment and homeostasis of energy expenditure. Recent …
response to the external environment and homeostasis of energy expenditure. Recent …
FXR1 regulation of parvalbumin interneurons in the prefrontal cortex is critical for schizophrenia-like behaviors
Parvalbumin interneurons (PVIs) are affected in many psychiatric disorders including
schizophrenia (SCZ), however the mechanism remains unclear. FXR1, a high confident risk …
schizophrenia (SCZ), however the mechanism remains unclear. FXR1, a high confident risk …
T‐type calcium channels as therapeutic targets in essential tremor and Parkinson's disease
LG Matthews, CB Puryear, SS Correia… - Annals of Clinical …, 2023 - Wiley Online Library
Neuronal action potential firing patterns are key components of healthy brain function.
Importantly, restoring dysregulated neuronal firing patterns has the potential to be a …
Importantly, restoring dysregulated neuronal firing patterns has the potential to be a …
T-type calcium channels in synaptic plasticity
N Leresche, RC Lambert - Channels, 2017 - Taylor & Francis
The role of T-type calcium currents is rarely considered in the extensive literature covering
the mechanisms of long-term synaptic plasticity. This situation reflects the lack of suitable T …
the mechanisms of long-term synaptic plasticity. This situation reflects the lack of suitable T …