Brain tumors are the most common solid tumors in children, and, unfortunately, many
subtypes continue to have a suboptimal long-term outcome. During the last several years …

Paediatric low-grade gliomas (also known as pLGG) are the most common type of CNS
tumours in children. In general, paediatric low-grade gliomas show clinical and biological …

Infant gliomas have paradoxical clinical behavior compared to those in children and adults:
low-grade tumors have a higher mortality rate, while high-grade tumors have a better …

Pediatric low-grade gliomas (pLGG) show heterogeneous responses to MAPK inhibitors
(MAPKi) in clinical trials. Thus, more complex stratification biomarkers are needed to identify …

Infant gliomas have paradoxical clinical behavior compared to those in children and adults:
low-grade tumors have a higher mortality rate, while high-grade tumors have a better …

Abstract On March 16, 2023, the FDA approved dabrafenib in combination with trametinib
(Tafinlar, Mekinist; Novartis Pharmaceuticals Corporation) for the treatment of pediatric …

Simple Summary Vincristine is a vinca alkaloid naturally occurring in Catharanthus roseus. It
belongs to antimitotic compounds, which arrest the cell cycle via disrupting microtubule …

Introduction A hallmark of pediatric low-grade glioma (pLGG) is aberrant signaling of the
mitogen activated protein kinase (MAPK) pathway. Hence, inhibition of MAPK signaling …

Management of pediatric low-grade glioma : Current Opinion in Pediatrics Management of
pediatric low-grade glioma : Current Opinion in Pediatrics Log in or Register Subscribe to …

In the new WHO 2021 Classification of CNS Tumors the chapter “Circumscribed astrocytic
gliomas, glioneuronal and neuronal tumors” encompasses several different rare tumor …