Bicyclo [1.1. 1] pentanes (BCPs) are important bioisosteres of 1, 4-disubstituted arenes, tert-
butyl and acetylenic groups that can impart physicochemical benefits on drug candidates …

Cross-electrophile coupling reactions of two Csp3–X bonds remain challenging. Herein we
report an intramolecular nickel-catalyzed cross-electrophile coupling reaction of 1, 3-diol …

In recent years, nucleophilic substitution of alcohols leading to the formation of the CC and C-
heteroatom bonds has become an attractive process used in the synthesis of organic …

Cellulose nanofibril (CNF) is a natural biodegradable biopolymer with excellent mechanical
and barrier properties. However, it is susceptible to moisture-induced deterioration of its …

Rufinamide is an antiepileptic drug to treat Lennox–Gastaut syndrome, in combination with
other medications. Rufinamide is one of the best-selling 5-membered ring heterocyclic …

Cinnarizine, cyclizine, buclizine, and meclizine belong to a family of antihistamines that
resemble each other in terms of a 1‐diphenylmethylpiperazine moiety. We present the …

We present the controlled monochlorination of aliphatic and benzylic hydrocarbons with only
1 equiv of substrate at 25–30° C using N-hydroxyphthalimide (NHPI) as radical initiator and …

Grignard reagents are commonly used as carbanion equivalents. Herein, we report an
example of Grignard reagents acting as halide nucleophiles to form alkyl iodides and …

The direct chlorination of C–H bonds has received considerable attention in recent years. In
this work, a metal-free protocol for hydrocarbon C–H bond chlorination with commercially …

A phenyltrimethylammonium tribromide-mediated nucleophilic substitution/oxygen
transformation reaction of benzyl halides with DMSO has been developed. In this transition …