ACG clinical guideline for the diagnosis and management of gastroesophageal reflux disease

PO Katz, KB Dunbar, FH Schnoll-Sussman… - Official journal of the …, 2022 - journals.lww.com
Gastroesophageal reflux disease (GERD) continues to be among the most common
diseases seen by gastroenterologists, surgeons, and primary care physicians. Our …

Proton pump inhibitor-induced gut dysbiosis and immunomodulation: current knowledge and potential restoration by probiotics

A Kiecka, M Szczepanik - Pharmacological Reports, 2023 - Springer
Proton pump inhibitors (PPIs) are the most commonly prescribed drugs for the treatment of
non-erosive reflux disease (NERD), ulcers associated with non-steroidal anti-inflammatory …

Proton pump inhibitors and risk of hip fracture: a meta-analysis of observational studies

TN Poly, MM Islam, HC Yang, CC Wu, YCJ Li - Osteoporosis International, 2019 - Springer
We performed a meta-analysis of relevant studies to quantify the magnitude of the
association between proton pump inhibitors (PPIs) and risk of hip fracture. Patients with PPIs …

Physiologic, pathophysiologic, and pharmacologic regulation of gastric acid secretion

ML Schubert - Current opinion in gastroenterology, 2017 - journals.lww.com
Physiologic, pathophysiologic, and pharmacologic regulation... : Current Opinion in
Gastroenterology Physiologic, pathophysiologic, and pharmacologic regulation of gastric …

Proton pump inhibitors and dementia: physiopathological mechanisms and clinical consequences

G Ortiz-Guerrero, D Amador-Muñoz… - Neural …, 2018 - Wiley Online Library
Alzheimer's disease (AD) is the most common type of dementia, mainly encompassing
cognitive decline in subjects aged≥ 65 years. Further, AD is characterized by selective …

Proton pump inhibitor use and risk of dementia: systematic review and meta-analysis

M Li, Z Luo, S Yu, Z Tang - Medicine, 2019 - journals.lww.com
Background: Proton pump inhibitors (PPIs) are an established kind of drugs used to the
treatment of most acid-related diseases. Some prospective studies have noticed that PPI use …

A pharmacovigilance study of association between proton pump inhibitor and dementia event based on FDA adverse event reporting system data

B Wu, Q Hu, F Tian, F Wu, Y Li, T Xu - Scientific reports, 2021 - nature.com
Proton pump inhibitor (PPI) was widely used around the world. Studies suggested conflicting
results between PPI treatment and dementia event. This study examined the association …

Systematic review with meta‐analysis: risk of adverse cardiovascular events with proton pump inhibitors independent of clopidogrel

R Batchelor, R Kumar… - Alimentary …, 2018 - Wiley Online Library
Background Clopidogrel's anti‐platelet effects may be attenuated by a pharmacokinetic
interaction with co‐prescribed proton pump inhibitors, which inhibit oxidative pathways that …

PPI long term use: risk of neurological adverse events?

M Novotny, B Klimova, M Valis - Frontiers in Neurology, 2019 - frontiersin.org
The purpose of this review study is to reveal a potential threat of one type of such widely
used and freely distributed drugs, which are proton pump inhibitors that might be the cause …

No association between proton pump inhibitor use and risk of dementia: Evidence from a meta‐analysis

S Hussain, A Singh, S Zameer… - Journal of …, 2020 - Wiley Online Library
Background and Aim A growing body of literature suggests the association between
dementia risk and proton pump inhibitor (PPI) use. Therefore, we aimed to investigate the …