Retinoic acid (RA), the major bioactive metabolite of retinol or vitamin A, induces a spectrum
of pleiotropic effects in cell growth and differentiation that are relevant for embryonic …

Nuclear receptors (NRs) are ligand-regulated transcription factors that regulate metabolism,
development and immunity. The NR superfamily is one of the major classes of drug targets …

Human nuclear receptors (NRs) are a family of forty-eight transcription factors that modulate
gene expression both spatially and temporally. Numerous biochemical, physiological, and …

The mechanism of transcriptional activation/repression of the nuclear receptors (NRs)
involves two main conformations of the NR protein, namely, the active (agonistic) and …

Humans perceive physical information about the surrounding environment through their
senses. This physical information is registered by a collection of highly evolved and finely …

Nuclear retinoic acid receptors (RARs) are ligand-dependent transcription factors involved
in various biological processes, such as embryogenesis, cell proliferation, differentiation …

Due to taxonomic positions and special living environments, marine organisms produce
secondary metabolites that possess unique structures and biological activities. This review …

In addition to apoptosis resistance and cell proliferation capacities, the undifferentiated state
also characterizes most cancer cells, especially leukemia cells. Cell differentiation is a …

We recently demonstrated that retinoic acid receptor-γ (RARγ) is overexpressed and acts as
a tumor promoter in hepatocellular carcinoma (HCC). The oncogenic activity of RARγ is …

Background Cosmetic treatments that inspire one's appearance to resemble their younger
portrait often utilize ingredients that confer acute effects, particularly hydration by creating …