Molecular engineering of NIR‐II fluorophores for improved biomedical detection
The development of fluorophores for the second near‐infrared window (NIR‐II, 1000–1700
nm) represents an emerging, significant, and vibrant field in analytic chemistry, chemical …
nm) represents an emerging, significant, and vibrant field in analytic chemistry, chemical …
Applications of bioluminescence in biotechnology and beyond
AJ Syed, JC Anderson - Chemical Society Reviews, 2021 - pubs.rsc.org
Bioluminescence is the fascinating natural phenomenon by which living creatures produce
light. Bioluminescence occurs when the oxidation of a small-molecule luciferin is catalysed …
light. Bioluminescence occurs when the oxidation of a small-molecule luciferin is catalysed …
Engineered tRNAs suppress nonsense mutations in cells and in vivo
Nonsense mutations are the underlying cause of approximately 11% of all inherited genetic
diseases. Nonsense mutations convert a sense codon that is decoded by tRNA into a …
diseases. Nonsense mutations convert a sense codon that is decoded by tRNA into a …
Fluorogenic probes for disease-relevant enzymes
Traditional biochemical methods for enzyme detection are mainly based on antibody-based
immunoassays, which lack the ability to monitor the spatiotemporal distribution and, in …
immunoassays, which lack the ability to monitor the spatiotemporal distribution and, in …
NIR-II bioluminescence for in vivo high contrast imaging and in situ ATP-mediated metastases tracing
Bioluminescence imaging has been widely used in life sciences and biomedical
applications. However, conventional bioluminescence imaging usually operates in the …
applications. However, conventional bioluminescence imaging usually operates in the …
Anti-quenching NIR-II molecular fluorophores for in vivo high-contrast imaging and pH sensing
The contrast and sensitivity of in vivo fluorescence imaging has been revolutionized by
molecular fluorophores operating in the second near-infrared window (NIR-II; 1000-1700 …
molecular fluorophores operating in the second near-infrared window (NIR-II; 1000-1700 …
Genetically encoded fluorescent biosensors illuminate the spatiotemporal regulation of signaling networks
EC Greenwald, S Mehta, J Zhang - Chemical reviews, 2018 - ACS Publications
Cellular signaling networks are the foundation which determines the fate and function of
cells as they respond to various cues and stimuli. The discovery of fluorescent proteins over …
cells as they respond to various cues and stimuli. The discovery of fluorescent proteins over …
Cancer-associated fibroblasts require proline synthesis by PYCR1 for the deposition of pro-tumorigenic extracellular matrix
EJ Kay, K Paterson, C Riera-Domingo, D Sumpton… - Nature …, 2022 - nature.com
Elevated production of collagen-rich extracellular matrix is a hallmark of cancer-associated
fibroblasts (CAFs) and a central driver of cancer aggressiveness. Here we find that proline, a …
fibroblasts (CAFs) and a central driver of cancer aggressiveness. Here we find that proline, a …
An optimized bioluminescent substrate for non-invasive imaging in the brain
Bioluminescence imaging (BLI) allows non-invasive visualization of cells and biochemical
events in vivo and thus has become an indispensable technique in biomedical research …
events in vivo and thus has become an indispensable technique in biomedical research …
ILC2-driven innate immune checkpoint mechanism antagonizes NK cell antimetastatic function in the lung
MJ Schuijs, S Png, AC Richard, A Tsyben… - Nature …, 2020 - nature.com
Metastasis constitutes the primary cause of cancer-related deaths, with the lung being a
commonly affected organ. We found that activation of lung-resident group 2 innate lymphoid …
commonly affected organ. We found that activation of lung-resident group 2 innate lymphoid …