[HTML][HTML] The GABA excitatory/inhibitory developmental sequence: a personal journey
Y Ben-Ari - Neuroscience, 2014 - Elsevier
The developing brain is talkative but its language is not that of the adult. Most if not all
voltage and transmitter-gated ionic currents follow a developmental sequence and network …
voltage and transmitter-gated ionic currents follow a developmental sequence and network …
Chloride transporters controlling neuronal excitability
JC Pressey, M de Saint-Rome… - Physiological …, 2023 - journals.physiology.org
Synaptic inhibition plays a crucial role in regulating neuronal excitability, which is the
foundation of nervous system function. This inhibition is largely mediated by the …
foundation of nervous system function. This inhibition is largely mediated by the …
The neuroprotective effects of carvacrol on ischemia/reperfusion-induced hippocampal neuronal impairment by ferroptosis mitigation
X Guan, X Li, X Yang, J Yan, P Shi, L Ba, Y Cao… - Life sciences, 2019 - Elsevier
Objective Cerebral ischemia is the most common type of neuronal injury and is
characterized by a reduction in the function and number of hippocampal neurons. Carvacrol …
characterized by a reduction in the function and number of hippocampal neurons. Carvacrol …
Chloride sensing by WNK1 involves inhibition of autophosphorylation
WNK1 [with no lysine (K)] is a serine-threonine kinase associated with a form of familial
hypertension. WNK1 is at the top of a kinase cascade, leading to phosphorylation of several …
hypertension. WNK1 is at the top of a kinase cascade, leading to phosphorylation of several …
Current view on the functional regulation of the neuronal K+-Cl− cotransporter KCC2
I Medina, P Friedel, C Rivera, KT Kahle… - Frontiers in cellular …, 2014 - frontiersin.org
In the mammalian central nervous system (CNS), the inhibitory strength of chloride (Cl−)-
permeable GABAA and glycine receptors (GABAAR and GlyR) depends on the intracellular …
permeable GABAA and glycine receptors (GABAAR and GlyR) depends on the intracellular …
Seizing control of KCC2: a new therapeutic target for epilepsy
Deficits in GABAergic inhibition result in the abnormal neuronal activation and
synchronization that underlies seizures. However, the molecular mechanisms responsible …
synchronization that underlies seizures. However, the molecular mechanisms responsible …
Genetically encoded impairment of neuronal KCC 2 cotransporter function in human idiopathic generalized epilepsy
The KCC 2 cotransporter establishes the low neuronal Cl− levels required for GABAA and
glycine (Gly) receptor‐mediated inhibition, and KCC 2 deficiency in model organisms results …
glycine (Gly) receptor‐mediated inhibition, and KCC 2 deficiency in model organisms results …
KCC2 overexpression prevents the paradoxical seizure-promoting action of somatic inhibition
Although cortical interneurons are apparently well-placed to suppress seizures, several
recent reports have highlighted a paradoxical role of perisomatic-targeting parvalbumin …
recent reports have highlighted a paradoxical role of perisomatic-targeting parvalbumin …
The neuronal K-Cl cotransporter KCC2 influences postsynaptic AMPA receptor content and lateral diffusion in dendritic spines
The K-Cl cotransporter KCC2 plays an essential role in neuronal chloride homeostasis, and
thereby influences the efficacy and polarity of GABA signaling. Although KCC2 is expressed …
thereby influences the efficacy and polarity of GABA signaling. Although KCC2 is expressed …
WNK1-regulated inhibitory phosphorylation of the KCC2 cotransporter maintains the depolarizing action of GABA in immature neurons
Activation of Cl−-permeable γ-aminobutyric acid type A (GABAA) receptors elicits synaptic
inhibition in mature neurons but excitation in immature neurons. This developmental “switch” …
inhibition in mature neurons but excitation in immature neurons. This developmental “switch” …