Flavonoids are a major group of phytoestrogens associated with physiological effects, and
ecological and social impacts. Although the estrogenic activity of flavonoids was reported by …

Steroid sulfatase (STS) is responsible for the hydrolysis of aryl and alkyl steroid sulfates and
therefore has a pivotal role in regulating the formation of biologically active steroids. The …

Inhibition of angiogenesis is an important new modality for cancer treatment. 2-
methoxyestradiol (2ME2) is a novel antitumor and antiangiogenic agent, currently in clinical …

The medicinal plant Withania somnifera is widely researched for its anti-inflammatory,
cardioactive and central nervous system effects. In Ayurveda, the major Traditional Indian …

BACKGROUND Despite significant advances in our understanding of the pathophysiology
of preeclampsia (PE), there are still many unknowns and controversies in the field. Women …

Drugs that affect microtubule dynamics, including the taxanes and vinca alkaloids, have
been a mainstay in the treatment of leukemias and solid tumors for decades. New, more …

Estrogens occurring naturally in the body are metabolized to catecholestrogens (2‐and 4‐
hydroxyestradiol) by the cytochrome P450 enzymes. 2‐Hydroxy catecholestrogens are …

Beta (β) cell dysfunction or loss is the common pathological feature in all types of diabetes
mellitus (diabetes). Resolving the underlying mechanism may facilitate the treatment of …

We hypothesized that the phytosterols β-sitosterol (BSS), β-sitosterol glucoside (BSSG), and
Moducare (MC; BSS: BSSG= 99: 1) could modulate the growth of estrogen-dependent …

It is widely believed that benign prostatic hyperplasia (BPH) is associated with aging. Thus,
the question arises whether or not a correlation exists between the well known prostatic …