Synthetic organic chemistry is based on the concourse of reagents and catalysts to achieve
the clean formation of new bonds, and appropriate protecting groups are required to prevent …

The last decade has witnessed a renaissance of peptides as drugs. This progress, together
with advances in the structural behavior of peptides, has attracted the interest of the …

Solid phase peptide synthesis (SPPS) provides the possibility to chemically synthesize
peptides and proteins. Applying the method on hydrophilic structures is usually without …

Many side reactions may occur at various stages of solid-phase or solution peptide
synthesis. 1 Some of these take place during activation of the C-terminus and coupling with …

The calcium-dependent lipopeptide antibiotics represent a promising new class of
antimicrobials for use in combating drug-resistant bacteria. At present, daptomycin is the …

CK2 is a ubiquitous serine/threonine protein kinase, which has the potential to catalyze the
generation of a large proportion of the human phosphoproteome. Due to its role in …

Solid‐phase peptide synthesis has contributed immeasurably to the understanding of the
chemistry and biology of peptides by enabling their ready preparation in small quantities up …

The sequence‐dependent, acid‐or base‐catalysed aspartimide formation is one of the most
serious side reactions in solid‐phase synthesis of peptides containing aspartic acid. In the …

Despite numerous optimizations in peptide synthesis, the formation of aspartimide remains a
significant side reaction that needs to be addressed. Herein, we introduce an approach that …

Microwave-assisted solid-phase syntheses of six “difficult” peptides, H-VVSVV-NH2 (3), H-
VVVSVV-NH2 (4), H-VIVIG-OH (5), H-TVTVTV-NH2 (6), H-VKDGYI-NH2 (7), and H-VKDVYI …