Transition metal-catalysed C–H activation has emerged as an increasingly powerful platform
for molecular syntheses, enabling applications to natural product syntheses, late-stage …

Highlights•A comprehensive compilation and analysis of FDA approved and under clinical
trials peptide-based therapeutics.•Clinical trial peptides pipeline analysis reveals emerging …

A large proportion of protein–protein interactions (PPIs) occur between a short peptide and a
globular protein domain; the peptides involved in surface interactions play important roles …

Transition-metal catalyzed C–H activation reactions have been proven to be useful
methodologies for the assembly of synthetically meaningful molecules. This approach bears …

Heteroarenes containing oxygen, nitrogen, and/or sulfur are important in numerous aspects
of chemistry and everyday life. C–H functionalization of heteroarenes represents the fastest …

Bioorthogonal late‐stage diversification of structurally complex peptides bears enormous
potential for drug discovery and molecular imaging, among other applications. Herein, we …

Disclosed herein is the visible‐light‐promoted deaminative C (sp3)− H alkylation of glycine
and peptides using Katritzky salts as electrophiles. Simple reaction conditions and excellent …

Over the last two decades, transition-metal catalyzed C–H functionalization of indoles has
emerged as an area of extensive research and tremendous progress has been made in this …

Over the last decade, high-valent cobalt catalysis has earned a place in the spotlight as a
valuable tool for C–H activation and functionalization. Since the discovery of its unique …

Cyclic peptides have attracted tremendous attention in the pharmaceutical industry owing to
their excellent cell penetrability, stability, thermostability, and drug-like properties. However …