The malignant tumor is a multi-etiological, systemic and complex disease characterized by
uncontrolled cell proliferation and distant metastasis. Anticancer treatments including …

Resistance to therapeutic treatment and metastatic progression jointly determine a fatal
outcome of cancer. Cancer metastasis and therapeutic resistance are traditionally studied as …

Rho GTPases are a family of small G proteins that regulate a wide array of cellular
processes related to their key roles controlling the cytoskeleton. Cancer is a multistep …

Cellular signaling networks are the foundation which determines the fate and function of
cells as they respond to various cues and stimuli. The discovery of fluorescent proteins over …

LOVTRAP is an optogenetic approach for reversible light-induced protein dissociation using
protein A fragments that bind to the LOV domain only in the dark, with tunable kinetics and …

Inhibition of HER2 in HER2-amplified breast cancer has been remarkably successful
clinically, as demonstrated by the efficacy of HER-kinase inhibitors and HER2-antibody …

The development and maintenance of tissues requires collective cell movement, during
which neighbouring cells coordinate the polarity of their migration machineries. Here, we …

RAS proteins are important direct activators of p110α, p110γ, and p110δ type I
phosphoinositide 3-kinases (PI3Ks), interacting via an amino-terminal RAS-binding domain …

Collective cell migration plays a crucial role in several biological processes, such as
embryonic development, wound healing and cancer metastasis. Here, we focused on …

Gastric carcinogenesis arises from complicated interactions among host, environmental and
bacterial factors, which cause genetic and epigenetic dysregulation of oncogenic and tumor …